骨形态发生蛋白2(BMP2)基因在内蒙古绒山羊不同时期皮肤毛囊中的表达  

Expression of BMP2 in the Skin and Hair Follicle from Different Stage in Inner Mongolia Cashmere Goat

作　　者：苏蕊[1] 李金泉[1] 张文广[1] 尹俊[1] 赵珺[1] 常子丽[1] 

机构地区：[1]内蒙古农业大学动物科技学院/动物遗传育种与繁殖自治区重点实验室,呼和浩特010018

出　　处：《中国农业科学》2008年第2期559-563,共5页Scientia Agricultura Sinica

基　　金：国家自然科学基金地区重点项目(39969002);内蒙古自治区自然科学基金重大项目〔200408020401);教育部"春晖计划"资助项目(2003年第二批);内蒙古绒山羊Hairkeratin;KAP基因的克隆及其表达模式的研究(30660122)

摘　　要：【目的】研究内蒙古绒山羊毛囊发育兴盛期和休止期BMP2基因在皮肤毛囊中的表达情况。【方法】功能分类基因芯片以及原位杂交技术。【结果】原位杂交结果表明,该基因在休止期毛囊毛干周围高表达,在兴盛期不表达;基因芯片结果显示,同兴盛期相比,休止期BMP2基因在皮肤中表达上调24.65倍。【结论】BMP2基因抑制内蒙古绒山羊皮肤毛囊发育,与维持皮肤毛囊处于休止期有关;该基因主要在皮肤毛囊的毛干周围发挥作用,从而达到维持皮肤毛囊发育处于休止期的作用。【Objective】To explore the expression of BMP2 in the skin and hair follicle in Inner Mongolia cashmere goat in different stages of hair follicle development. Try to explain the mode of action of these genes during the development and cycling of hair follicle【.Method】 GEArray S Series Stem Cell Array（Supper Array）and in situ hybridization were adopted. 【Result】The results show that the expression of BMP2 was up-regulated in the skin in telogen. Whereas it expressed weakly in anagen.【Conclusion】The results indicate that BMP2 mRNA express highly around the hair shaft during the telogen. It may be related to keeping hair follicle in telogen.

关 键 词：BMP2 毛囊 表达 原位杂交 基因芯片 

分 类 号：S827[农业科学—畜牧学] S827.1[农业科学—畜牧兽医]