老年原发性高血压患者脉压与大动脉扩张性、内皮功能关系的研究  

Clinical study of relationship between pulse pressure and large artery distensibility and endothelial function in old patients with hypertesion.

作　　者：吴敏琴[1] 张俊[1] 

机构地区：[1]川北医学院附属医院心内科,四川南充637000

出　　处：《四川医学》2008年第2期157-159,共3页Sichuan Medical Journal

摘　　要：目的研究老年原发性高血压（EH）患者脉压（PP）与大动脉扩张性、内皮功能的关系。方法选择69例按PP值分成4组,应用B超对颈动脉、肱动脉进行扫查,在静息、反应性充血时和舌下含服硝酸甘油后对肱动脉内径进行检测。结果颈总动脉舒张期直径（DD）随PP增大而增加,收缩期与舒张期直径之差（DS-D）及DS-D/DD却随PP增大而减小,PP与IMT呈正相关关系,其相关性强于SBP、DBP、MAP。加压充血后,肱动脉管径平均扩增（Flow-MD）3%-13%,随PP增大,Flow-MD逐渐减小,各组差异有统计学意义（P〈0.05）。结论PP增大与高血压患者大动脉扩张性降低、管壁增厚,内皮功能受损关系密切。Objective To explore relationship between PP and Large artery distensibility and endothelial function in old patientes with hypertension.Methods 69 patients with hypertension were selected, Divided all patients into 4 groups by PP. B-mode ultrasound was applied to scan carotid artery, brachial artery during reactive hyperemia caused by endothelium-dependent dilatation and the diameter after sublingual glyceryl trinitrate induced by endothelium-independent dihtation. Results In higher PP groups, diastolic diameter（ DD）Of carotid artery was also bigger. However, the difference between diastolic and systoltc diameter（DS- D）and DS-D/DD were lower in higher PP groups.PP had more positive correlativity with IMT than SBP,DBP and MAP. The bigger PP, the less Flow-mediated dilation（Flow- MD）. These difference were significant. Conclusion Augmentation of PP was closely related to a decrease in large artery distensibility and a reduction in endothelial function in patients with hypertension.

关 键 词：高血压 脉压 大动脉扩张性 内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病]