新型含悬挂羧基聚乳酸的制备及其血液相容性和细胞粘附性  

Preparation of Functionalized PLA with Pendant Carboxyl and Its Blood Compatibility and Cell Adhesion

作　　者：王蔚[1] 贾小华[1] 刘媛[1] 王亮[1] 袁直[1] 汤石明[2] 刘民[2] 汤华[2] 

机构地区：[1]南开大学高分子研究所,功能高分子材料教育部重点实验室,天津300071 [2]天津医科大学天津市生命科学中心实验室,天津300070

出　　处：《高等学校化学学报》2008年第2期433-435,共3页Chemical Journal of Chinese Universities

基　　金：国家“九七三”计划(批准号:2005CB623904)资助

摘　　要：Biodegradable α-hydroxyl polyesters,such as poly(lactic acid)(PLA)and poly(lactic-co-glycolic acid)(PLGA)were investigated as scaffolds for tissue engineering.However,polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells.In this study,the functional polylactide with pendant carboxyl(PLMACA)was synthesized,which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA.The structure and composition of PLMACA were confirmed via {}1H NMR spectrum and the compatibilities for blood and cell were stu-{died.} The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion.Biodegradable α-hydroxyl polyesters, such as poly （lactic acid） （PLA） and poly （lactic-co-glycolic acid） （PLGA） were investigated as scaffolds for tissue engineering. However, polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells. In this study, the functional polylactide with pendant carboxyl（PLMACA） was synthesized, which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA. The structure and composition of PLMACA were confirmed via ^1H NMR spectrum and the compatibilities for blood and cell were studied. The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion.

关 键 词：聚乳酸 血液相容性 内皮细胞 粘附 

分 类 号：O631.11[理学—高分子化学]