妊娠期肝内胆汁瘀积症孕妇肝功能指标、S/D值及NST与围生儿预后的关系  

Relationship of liver function,blood flow of fetal umbilical artery and non stress test in patients with intrahepatic cholestasis of pregnancy

作　　者：徐博[1] 黄作香[1] 张小莎[1] 

机构地区：[1]三峡大学第三临床医学院葛洲坝中心医院妇产科,湖北宜昌443002

出　　处：《中国妇幼保健》2008年第5期605-607,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨妊娠期肝内胆汁瘀积症孕妇肝功能指标、胎儿脐动脉血流测定及产前胎心监护对新生儿预后的预测价值。方法:测定肝功能指标、超声多普勒测定胎儿脐动脉血流速度比值(non-stress test,S/D)及胎心监护仪监测胎心率(NST),记录分娩方式、新生儿出生Apgar评分等。结果:随着肝功能指标的异常升高,异常S/D值和NST的发生率显著增高(P<0.05);当伴有异常肝功能指标、S/D值或NST结果时,新生儿窒息发生率和因胎儿宫内窘迫而施剖宫产率明显增加。结论:肝功能、S/D值及NST结果与围产儿缺氧密切相关,是判断新生儿预后的可靠和重要的指标。Objective： To explore the predicting value of liver function of mothers, determination of the blood flow of fetal umbilical artery （S/D）, non - stress test （NST） results in the prognosis of the newborns. Methods： Liver function, S/D, NST results in 110 cases of intrahepatic cholestasis of pregnancy （ICP） were determined by radioimmunoassay, color Doppler ultrasonic instrument, and fetal electronic ward ship instrument, respectively. The delivery modes and postnatal Apgar scores were recorded. Results： Liver function levels increased the incidence of abnormal S/D and NST in a dose - dependent manner （ P 〈 0. 05 ）. The occurrence rate of apnea in the newborn and cesarean section rate due to fetal distress were significantly increased in the groups of abnormal liver function or S/D or NST. Conclusion： Liver function, S/D, and NST are closely associated with apnea in the newborn, may be the reliable and important prognostic factors for predicting the prognosis of the newborns of women with ICP.

关 键 词：妊娠期肝内胆汁瘀积症 肝功能 脐动脉血流 无负荷试验 

分 类 号：R714.25[医药卫生—妇产科学]