妊娠期高血压疾病患者血浆总同型半胱氨酸水平监测及其干预治疗的研究  

Levels of plasma total homocysteine in the patients with hypertensive disorder complicating pregnancy and the study of interventional therapy

作　　者：张建鸿[1] 黄素然[1] 丁少波[1] 肖丽娟[1] 杨红星 何瑞荣[1] 黎普茜[1] 

机构地区：[1]广东省东莞市人民医院,523018 [2]广东省东莞市万江医院,523050

出　　处：《中国妇幼保健》2008年第5期610-612,共3页Maternal and Child Health Care of China

基　　金：广东省科技计划基金资助项目〔2007B080702046〕

摘　　要：目的:研究血浆总同型半胱氨酸(tHcy)水平和血清叶酸、维生素B12(VitB12)水平与妊娠期高血压疾病的关系并进行干预治疗研究。方法:测定350例妊娠期高血压疾病患者(A组)和350例正常晚期妊娠妇女(B组)血浆tHcy水平和血清叶酸、VitB12水平,并对妊娠期高血压疾病伴高同型半胱氨酸(Hcy)血症患者应用叶酸联合甲钴胺进行干预治疗(给予叶酸5mg,每日3次,甲钴胺500μg,每日1次,疗程4周),测定治疗前后患者血浆tHcy水平和血清叶酸、VitB12水平。结果:血浆tHcy水平A组显著高于B组(P<0.01),血清叶酸、VitB12水平A组显著低于B组(P<0.01);A组中83例伴高Hcy血症患者经叶酸联合甲钴胺干预治疗4周后,血浆tHcy水平显著下降(P<0.01),血清叶酸、VitB12水平显著上升(P<0.01)。结论:妊娠期高血压疾病患者血浆tHcy水平显著上升,血清叶酸、VitB12水平显著下降,叶酸联合甲钴胺干预治疗能使妊娠期高血压疾病伴高Hcy血症患者血浆tHcy水平显著下降。Objective： To study the relationship between the levels of plasma total homocysteine （tHcy）, serum folic acid, serum vitamin B12 （VitB12） and hypertensive disorder complicating pregnancy and to explore the efficacy of interventional therapy. Methods： The levels of plasma tHcy and serum folic acid, VitB12 in 350 patients with hypertensive disorder complicating pregnancy （group A） and 350 cases of normal late pregnancy （group B） were measured. The patients in group A accompanied by hyper homocysteinemla were intervened with folic acid and methylcobalamin （folic acid 5mg, po, tid, and methylcobalamin, 500μg, po, qd, for4 weeks） . Results： The levels of plasma tHcy were significantly higher in group A than that in group B （ P 〈 0. 05 ） , the levels of serum folic acid and VitB12 were significantly lower in group A than that in group B （P 〈 0.01 ） . The levels of plasma tHcy in 83 patients with hypertensive disorder complicating pregnancy accompanied by hyperhomocysteinemia were significantly decreased after 4 weeks＇treatment compared with that before treatment （P 〈 0. 01 ）, and the levels of serum folic acid and VitB：2 were significantly increased after 4 weeks＇treatment compared with that be- fore treatment （P 〈 0. 01 ） . Conclusion： The levels of plasma tHcy in the patients with hypertensive disorder complicating pregnancy are significantly elevated, and the levels of serum folic acid and VitB12 are significantly decreased. Folic acid combined with methylcobalamin can significantly reduce the levels of plasma tHcy in the patients with hypertensive disorder complicating pregnancy accompanied by hyperhomocysteinemia.

关 键 词：妊娠期高血压疾病 血浆 总同型半胱氨酸 

分 类 号：R714.246[医药卫生—妇产科学]