充液胶囊的研究进展  

A review on liquid-filled hard gelatin capsules

作　　者：马家骅[1] 杨明[1] 曾敏[1] 陈雪梅[1] 兰洁[1] 

机构地区：[1]成都中医药大学温江校区药学院,四川成都611130

出　　处：《中国中药杂志》2008年第5期602-605,共4页China Journal of Chinese Materia Medica

摘　　要：近年来新剂型不断涌现,充液胶囊就是其中之一,其采用明胶或羟丙基甲基纤维素(HPMC)外壳,以全新概念的固体剂型液体释放而备受关注。作者主要介绍了充液胶囊的应用、制备、质量评价及其前景展望,重点介绍了充液胶囊的应用与制备,指出充液胶囊适于各种液体或半固体状天然植物提取物,并可达到不同的释药目的。其制备可采用液体灌装硬胶囊技术,影响因素主要有灌装材料的性质和设备情况。制剂常通过囊壳的水分、溶出度等指标进行评价。同时,指出这一新型胶囊将存在大量的市场机会,为企业带来丰厚的商业利润。Novel dosage forms emerges more and more in recent years. One of them is liquid-filled hard gelatin capsules, which adopt gelatin or the hydroxypropyl methyl cellulose （HPMC） as capsule shell. The liquid-filled hard gelatin capsule is increasingly getting attention because of its new-concept dosage form design, which deliver liquid drugs by solid form. The paper mainly introduces application , pharmaceutical manufacturing, quality assessment, prospect of liquid-filled hard gelatin capsules, and focuses on the application and pharmaceutical manufacturing （preparation） of liquid-filled capsule. It is suggested that the capsule is suitable for various liquid or semi-solid natural plant extract and achieve different release profiles. The preparation adopted liquid-filled hard capsules technology. The influence factors concluded property of shell and device of filling. The quality was often evaluated by moisture content of capsule shell, dissolution rate etc. At the same time, it was pointed out that the new dosage form has remarkable marketing prospect and bring profits for enterprises.

关 键 词：充液胶囊 应用 制备 质量评价 展望 

分 类 号：R94[医药卫生—药剂学]