狼疮性肾炎患者40例临床病理分析  

Clinical and pathological manifestation analysis in 40 patients with lupus nephritis

作　　者：王彩虹[1] 赵建民[1] 

机构地区：[1]内蒙古赤峰市医院肾内科,024000

出　　处：《临床内科杂志》2008年第2期90-92,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨狼疮性肾炎(LN)的病理类型与临床及实验室检查的关系。方法对40例狼疮性肾炎患者进行肾活检(其中9例重复肾活检)及病理分型,分析各病理类型的临床特点、实验室检查特点、临床活动性及肾脏病理活动性。结果所有患者均有病理学异常,Ⅳ型最多见(占42.5%),Ⅳ型LN高血压、肾功能不全及血液系统损害发生率高,血清补体C3下降明显;临床活动性及肾脏病理活动性明显;Ⅳ型、Ⅴ型LN肾病综合征发生率高。结论狼疮性肾炎的病理类型与临床表现、实验室检查有一定联系;根据狼疮性肾炎的临床表现、实验室检查可以大致推测其病理类型,估计肾损害的严重程度;恰当地治疗可以缓解病情,改善预后。Objective To evaluate the relation between pathologic type of lupus nephritis （LN） and its clinical findings and the laboratory examination. Method The renal biopsy was made in 40 cases of lupus nephritis （9 cases were subjected by repeated biopsy） and were classified. To analyse the clinical features and the laboratory examination features and clinical activity and renal pathologic activity of pathologic types. Results All patients have damage in renal, Ⅳ type LN was most common（42.5% ）. Among Ⅳ type LN, there was high incidence in hypertension, renal failure, the damage in blood system, C3 decreasing,It was marked that clinical activity and renal pathologic activity; Ⅳ type and Ⅴ type LN there were high incidence in nephrotie syndrome. Conclusions There is a relation between LN pathological chang and LN clinical manifestation and laboratory examination, The clinical findings and the laboratory examination estimate type of pathology and severe of renal damage. Appropriate treatment can help to improve the pathological type and long-term prognosis.

关 键 词：狼疮性肾炎 临床症状 病理学 

分 类 号：R593.242[医药卫生—内科学] R692[医药卫生—临床医学]