IVF-ET后补充小剂量雌激素不改善妊娠率  

Estrogen Supplementation during Luteal Phase in IVF-ET Did Not Improve the Clinical Pregnancy Rate

作　　者：徐冰[1] 赵晓明[1] 洪燕[1] 孙赟[1] 郑中[1] 李卫平[1] 

机构地区：[1]上海交通大学医学院附属仁济医院生殖医学中心,上海200001

出　　处：《生殖与避孕》2008年第2期95-98,共4页Reproduction and Contraception

基　　金：上海市浦东新区科技专项基金资助项目;项目编号:PKJ2005-33

摘　　要：目的:探讨体外受精-胚胎移植(IVF-ET)黄体支持中补充小剂量雌激素(E2)对妊娠率的影响。方法:①回顾性分析912个IVF-ET周期,根据黄体支持方案将其分为A组(511个周期),给予黄体酮80mg/d;B组(401个周期),给予黄体酮80mg/d+补佳乐2mg/d,比较组间妊娠率;②按照hCG日与ET日E2比值,分为<4.0组(291个周期)和≥4.0组(220个周期),比较二组妊娠率,了解E2下降程度与妊娠的关系;③另选择IVF超排卵妇女因某种因素未行移植(24个周期)和自然周期排卵妇女(32个周期)比较黄体中期E2水平,以了解超促排卵对黄体中期E2的影响。结果:黄体期补充与不补充E2组间种植率和妊娠率均无差异(P>0.05);E2下降程度不同的二组间种植率和妊娠率也无差异(P>0.05)。IVF超排妇女黄体中期E2水平明显高于自然周期妇女(P<0.01)。结论:取卵后E2水平下降不影响IVF结局,补充E2进行黄体支持不能改善IVF妊娠率。Objective： To evaluate the impact of estrogen used as luteal support on clinical outcome of in vitro fertilization and embryo transfer（IVF-ET）. Methods： 1） A total of 912 IVF-ET cycles were retrospectively analyzed. The clinical outcome was compared between two IVF-ET groups with different luteal support, group A （511 cycles） was supplied only progesterone （80 mg/d）; group B （401cycles） was supplied progesterone （P, 80 mg/ d） and estrogen （E2, 2 mg/d）. 2） The clinical outcome in two groups which divided according to the E2（dhCG） / E2（dET） 〈 4.0 （291 cycles） and≥ 4.0 （220 cycles）. 3） The E2 level in the middle luteal phase was compared in IVF COH cycles and the nature cycles. Results： There was no difference in clinical outcome between the two groups with or without E2 supplied （P〉0.05）, two groups with different declined levels of E2 had the same outcome. The E2 level oflVF COH cycles was significant higher than that of nature cycles. Conclusion： The declined level orE2 did not affect the clinical outcome of IVF-ET and there was no beneficial effect in adding estrogen to luteal support.

关 键 词：体外受精-胚胎移植(IVF-ET) 雌激素 临床妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]