药物中水合肼残留量的气相色谱分析  

Determination of hydrazine in drugs by gas chromatography with derivatization

作　　者：周延生[1] 李赛钰[1] 韩东升[2] 刘军[1] 

机构地区：[1]山东省分析测试中心,济南250014 [2]山东省化工研究院,济南250014

出　　处：《分析试验室》2008年第3期84-86,共3页Chinese Journal of Analysis Laboratory

摘　　要：建立了用气相色谱-氮磷检测器（GC-NPD）测定药物中水合肼的新方法。其萃取和衍生采用同一种试剂-丙酮,一步完成,可简单快速地定量检测药物中水合肼的残留量,其检出限为41.0μg/kg;相对标准偏差小于4.1%;回收率在101.5%-107.8%。已用于药物中水合肼的残留量分析。A rapid and simple method has been developed for the determination of hydrazine in drugs using acetone as a derivative reagent and an extractant to quantitatively extracts and convert hydrazine to from a stable derivative in a single step. The derivatives in the acetone solution was analyzed by gas chromatography with a nitrogen-phosphorus detector （GC-NPD）. The detection limit was 41.0μg/kg, the relative standard deviation was less than 4.1%, and the recoveries were in the range of 101.5 % - 107.8 %. This method has been applied to the determination of hydrazine in drugs

关 键 词：水合肼 药物 气相色谱 衍生 

分 类 号：O657.7[理学—分析化学]