抗疱疹病毒药——缬昔洛韦  

A NOVEL ANTIHERPETIC DRUG——VALACICLOVIR

作　　者：虞瑞尧[1] 

机构地区：[1]解放军总医院皮肤科

出　　处：《中国新药杂志》1997年第6期409-411,共3页Chinese Journal of New Drugs

摘　　要：缬昔洛韦是新一代抗疱疹病毒药，为阿昔洛韦的Ｌ缬氨酰酯盐酸盐，是阿昔洛韦的前药。其口服生物利用度比阿昔洛韦强，已经ＦＤＡ批准用于治疗带状疱疹和原发、复发性生殖器疱疹。缬昔洛韦１０００ｍｇ，ｔｉｄ用７ｄ和５００ｍｇ，ｂｉｄ用５ｄ能达到与阿昔洛韦同样疗效。其不良反应发生率与安慰剂相同。Valaciclovir is a novel antiherpetic drug.It is a prodrug of aciclovir and it is a L valyl ester of aciclovir.It is developed by Glaxo Wellcome company and approved by FDA for treatment of herpes zoster,and first or reccurrent episodes of genital herpes.Valaciclovir in regimen of 1 000 mg 3 times daily for 7 days and 500 mg twice daily for 5 days are as effective as aciclovir in regimen of 800 mg five times daily for 7 days.The side effect rates of valaciclovir are similar to that of placebo.

关 键 词：缬昔洛韦 带状疱疹 生殖器疱疹 药理 

分 类 号：R986[医药卫生—药品]