温中消痰方对寒邪干预S_180荷瘤鼠相关因素的影响  

Influence of Recipe Wenzhongxiaotan on Correlation Factor to S180 Bearing Cancer Mouse Interfered by Cold Pathogenic Factor

作　　者：党海珍[1] 魏品康[2] 庄兴俊[1] 宋远民[1] 姜忠华[1] 

机构地区：[1]中国人民解放军第401医院肿瘤中心,山东青岛266071 [2]中国人民解放军第二军医大学附属长征医院中医科,上海200003

出　　处：《中国中医药信息杂志》2008年第3期33-35,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的探讨温中消痰方对寒邪干预S180荷瘤小鼠的影响及对部分相关性指标进行研究。方法用温中消痰方治疗冰水干预的S180荷瘤小鼠,同时用消痰散结方组及化疗组作为对照,观察温中消痰方治疗后小鼠形态学、肛温的变化及各组肿瘤的生长速度、体积的变化,并用放免法检测小鼠血浆中血栓素B2(TXB2)的表达情况。结果温中消痰方组动物畏寒的形态学表现较其它组出现晚、历时短,肛温下降幅度较小;温中消痰方组、消痰散结方组、化疗组(FT-207)的抑瘤率分别为86.69%、75.29%、87.55%;温中消痰方组TXB2水平与消痰散结方组、化疗组相近,与寒模组比较差异显著(P<0.01),与模型组比较,差异无统计学意义(P>0.05)。结论温中消痰方对寒邪干预S180荷瘤小鼠肿瘤的生长有抑制作用,并下调TXB2的表达,其抑瘤率和FT-207、消痰散结方相近。Objective To discuss the influence of Recipe Wenzhongxiaotan to S180 bearing cancer mouse interfered by cold pathogenic factor and study correlation factor index, Methods To treat S180 bearing cancer mouse by interfere in ice water with Recipe Wenzhongxiaotan, with the control of Recipe Xiaotansanjie group and chemotherapy group, the change of morphology and rectal temperature in mouse, growth velocity and volume in tumor after treatment with Recipe Wenzhongxiaotan were observed, and TXB2 in plasma of mouse was detected by RIA, Results It showed late and short in chilly morphology and rectal temperature amplitude small than other groups in Recipe Wenzhongxiaotan group. The rate to restrain tumor growth was 86.69%, 75.29%, 87,55% in Recipe Wenzhongxiaotan group, Recipe Xiaotansanjie group and chemotherapy group （FT-207）, respectively. TXB2 was near in Recipe Xiaotansanjie group and chemotherapy group and the difference was significant compared cold model group （P〈0.01）, and was not statistically significant with model group （P〉0.05） in Recipe Wenzhongxiaotan. Conclusions It may be restrain tumor growth which S180 tumor-bearing mice interfered by cold pathogenic factor and degrade TXB2 in Recipe Wenzhongxiaotan, the rate to restrain tumor growth was near to FT-207 and Recipe Xiaotansanjie.

关 键 词：温中消痰方 消痰散结方 S180小鼠 FT-207 血栓素B2 

分 类 号：R285.5[医药卫生—中药学]