紫杉醇糖被复脂质体的制备及其在小鼠体内的组织分布  

Preparation of Mannose-covered Liposomes of Paclitaxel and Its Tissue Distribution in Mice

作　　者：黄冲[1] 奚连[1] 裘渊[1] 杨敏[1] 贺芬[1] 

机构地区：[1]上海医药工业研究院,药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2008年第3期182-186,共5页Chinese Journal of Pharmaceuticals

摘　　要：用HPLC法测定小鼠单剂量(10mg/kg)尾静脉注射自制紫杉醇糖被复脂质体或市售紫杉醇注射剂后的心、肝、脾、肺、肾和血浆的药物浓度。结果表明,糖被复脂质体组紫杉醇主要被肺摄取,在肺部的滞留时间明显延长,肺中AUC为注射剂的9.6倍;并减少了肝、脾组织的蓄积量。说明此紫杉醇糖被复脂质体在小鼠体内的分布优于注射液,有明显的肺靶向性。The mannose-covered liposomes loaded with paclitaxel were prepared. A HPLC method was established for the determination of paclitaxel in tissues （heart, liver, spleen, lung and kidney） and plasma of mice. The paclitaxel mannose-covered liposomes and paclitaxel injection were injected intravenously with single dose of 10mg/kg to mice, respectively. The results showed that in the mannose-covered liposomes group, the major amount of paclitaxel was absorbed in lung and the residence time in lung was longer than that of injection group. The AUC in lung of the former was increased by 9.6-fold as compared with the latter. It indicated that the mannose-covered liposomes had less drug accumulation in liver and kidney, and could target to the lung.

关 键 词：紫杉醇 糖被复脂质体 制备 组织分布 

分 类 号：R944.9[医药卫生—药剂学]