布格呋喃及其胶囊的含量和有关物质的HPLC法测定  

Determination of Content and Related Substances of Buagafuran and Its Capsules by HPLC

作　　者：夏学军[1] 金笃嘉[1] 任怡[1] 刘玉玲[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《中国医药工业杂志》2008年第3期199-202,共4页Chinese Journal of Pharmaceuticals

基　　金：863重大科技专项(2002AA2Z3117)

摘　　要：建立了HPLC法测定布格呋喃及其胶囊的含量和有关物质。采用C8柱,流动相为乙腈-水(78∶22),柱温40℃。含量测定波长为196nm,有关物质采用196nm和240nm双波长自动检测。布格呋喃在0.01～0.5mg/ml范围内线性关系良好。布格呋喃胶囊的平均回收率为100.3%,RSD为0.4%。A RP-HPLC method was established for the determination of the content and related substances of buagafuran and its capsules. A C8 column was used with the mobile phase ofacetonitrile-water（78 ：22） and column temperature of 40℃. The detection wavelength for content was 196nm, and for related substances was 196nm and 240nm. The linear range of buagafuran was 0.01 -0.5mg/ml. The average recovery ofbuagafuran capsules was 100.3%, with RSD of 0.4%.

关 键 词：布格呋喃 胶囊 有关物质 高效液相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]