出生后免疫在阻断乙型肝炎病毒母婴传播中的作用  

Function of newborn vaccination on blocking hepatitis B virus transmission from mother to child

作　　者：张平[1] 张玉荣[1] 陈静[1] 国心[1] 郝金玉[1] 朱理珉[1] 

机构地区：[1]天津市传染病医院,300192

出　　处：《中华传染病杂志》2008年第2期86-87,共2页Chinese Journal of Infectious Diseases

摘　　要：目的探讨HBV感染母亲所产婴儿HBV感染情况以及生后免疫效果。方法以新生儿出生2h内静脉血定量检测HBsAg作为新生儿HBV感染指标，治疗组新生儿在出生后0、1、4、6个月使用重组乙型肝炎疫苗（酵母）各一次，每次10μg，乙型肝炎免疫球蛋白用量根据新生儿出生后即刻检测结果而定，使新生儿体内的抗-HBs水平达到500～600U／L，6个月龄评价疗效；与以未针对性免疫的6个月龄婴儿作为对照组进行比较。结果治疗组共纳入1460例婴儿，189例出生后感染，6个月龄时15例HBV阳性，占1．0％；对照组共纳入653例，6个月龄时64例HBV阳性，占9．8％（P〈0．01）。结论生后免疫在阻断HBV母婴传播方面有一定意义。Objective To investigate the prevalence of hepatitis B virus （HBV） infection in infants whose mother were infected with HBV and the efficacy of newborn vaccination. Methods HBV infection of neonate was defined as HBsAg positive by detecting venous blood within 2 hours after birth. The neonates in vaccinated group were vaccinated with recombinant hepatitis B vaccine （yeast） at 0, 1, 4, 6 month after birth, 10 μg each time, respectively. The dosage of hepatitis B immunoglobulin depended on the blood test results of the neonates. The anti-HBs levels of the neonates were expected to be 500-600 U/L and the vaccination efficacy was evaluated on 6 months old. Six-month old infants who were not vaccinated were recruited in control group. Results One thousand four hundred and sixty infants were recruited in vaccinated group. One hundred and eighty-nine were infected with HBV after birth and 15 （1.0%） were HBV positive when they were 6 months old. Six hunderd and fifty-three infants were recruited in control group. Sixty-four （9.8%） were HBV positive when they were 6 months old （P 〈 0.01）. Conclusion Newborn vaccination is very important in blocking HBV transmission from mother to child.

关 键 词：肝炎疫苗 乙型 肝炎病毒 乙型 疾病传播 垂直 免疫球蛋白类 

分 类 号：R512.62[医药卫生—内科学] R714.431[医药卫生—临床医学]