注射用加替沙星与注射用多索茶碱的配伍稳定性考察  

Compatible Stability of Gatifloxacin for Injection with Doxofylline for Injection

作　　者：杨继章[1] 徐秀娟[2] 刘瑞琴[1] 杨树民[1] 郑树利[3] 

机构地区：[1]河北医科大学第一医院药剂科,石家庄市050031 [2]河北医科大学口腔医院,石家庄市050017 [3]河北医科大学药学院,石家庄市050017

出　　处：《中国药房》2008年第8期603-605,共3页China Pharmacy

基　　金：河北省医学科学研究重点课题(04177)

摘　　要：目的:考察注射用加替沙星与注射用多索茶碱分别在0·9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法:在室温((20±1)℃)条件下,分别观察及测定8h内配伍液的外观、pH值及紫外吸收光谱的变化,并用紫外双波长分光光度法测定加替沙星与多索茶碱的含量。结果:2药配伍后8h内,除在5%葡萄糖注射液中配伍后,6h时多索茶碱的含量降低外,其外观、pH值、含量和紫外吸收峰形均无明显变化。结论:注射用加替沙星与注射用多索茶碱可在0·9%氯化钠注射液或5%葡萄糖注射液中配伍使用,但在5%葡萄糖注射液中宜4h内滴注完毕。OBJETIVE： To study the compatibility of gatifloxacin for injection with doxofylline for injection in 0.9% sodium chloride or 5% glucose injection. METHODS： Within 8 hours at room temperature （20± 1）℃, the change of the mixture in appearance, pH value and UV absorption spectra were respectively observed, and the contents of gatifloxcation and doxofylline were determined by dual ultraviolet spectrophotometry. RESULTS： No significant change was noted in appearance, pH value and content and UV absorption spectra within 8 hours after mixing except the content of doxofylline in 5% glucose injection was reduced at 6h. CONCLUSION： Gatifloxacin for injection can be mixed with doxofylline for injection in 0.9% sodium chloride injection or 5% glucose injection to use, but the mixture in 5% glucose injection should be used up within 4h.

关 键 词：注射用加替沙星 注射用多索茶碱 配伍 稳定性 紫外分光光度法 

分 类 号：R927.11[医药卫生—药学]