苯磺酸左旋氨氯地平联用脑复康治疗血管性痴呆的临床研究  

Clinical Study on Levoamlodipine Besylate Combined with Piracetam in the Treatment of Vascular Dementia

作　　者：张雪羽[1] 陈兰英[1] 张秀丽[1] 

机构地区：[1]河北北方学院附属第二医院,张家口市075100

出　　处：《中国药房》2008年第8期607-608,共2页China Pharmacy

摘　　要：目的:观察苯磺酸左旋氨氯地平联用脑复康治疗血管性痴呆(VD)的疗效。方法:将66例VD患者随机分为治疗组、对照组各33例。治疗组用苯磺酸左旋氨氯地平2·5～5mg,每日1次,脑复康0·8g,每日3次,共服3个月;对照组用脑复康0·8g,每日3次,共服3个月。其他根据血糖、血压、血脂相应基础治疗,观察3个月。治疗前、后用简易精神状态评估量表(MMSE)、日常生活功能量表(ADL)、长谷川痴呆量表(HDS)、痴呆严重程度临床评定量表(WMS),评价2组患者认知功能、智能状态。结果:治疗组用药后MMSE(22·48±3·25)分,ADL(25·16±8·96)分,HDS(23·14±2·91)分,WMS(71·14±19·01)分;对照组用药后MMSE(20·56±3·18)分,ADL(29·74±13·01)分,HDS(20·41±6·25)分,WMS(60·35±20·60)分。治疗组较对照组症状明显改善,差异有统计学意义(P<0·05或P<0·01)。结论:苯磺酸左旋氨氯地平联用脑复康,可明显改善患者的认知功能和智能状态,提高生活质量,治疗VD有效。OBJECTIVE： To observe the efficacy of levoamlodipine besylate combined with piracetam for vascular dementia （VD）. METHODS： 66 patients with VD were enrolled： 33 （treatment group） were assigned to receive Levoamlodipine besylate 2.5-5 mg q.d plus piracetam 0.8 g tid for 3 months, and another 33 （control group） to receive piracetam 0.8 g tid plus basic treatment based on patients＇ blood glucose, blood pressure and blood lipid levels. The patients were given 3 - month follow- up. Mini- Mental State Examination （MMSE）, Activity of Daily Living Scale （ADL）, Hasegawa Dementia Scale （HDS） and Wechsler Memory Scale （WMS） were used to evaluate the patient＇ s cognitional function and mental state before and after treatment. RESULTS： MMSE, ADL, HDS, and WMS scores after treatment were （22.48±3.25）, （25.16±8.96）, （23.14±2.91）, （71.14±19.01）, respectively in treatment group versus （20.56±3.18）, （29.74±13.01）, （20.41±6.25）, （60.35±20.60）, respectively in control group. The treatment had a better improvement in symptoms than control group did and there was statistical difference between groups （P 〈 0.05 or P 〈 0.01）. CONCLUSION： Levamlodipine besylate combined with piracetam could significantly improve patient＇s cognitional function and mental state as well as patients＇ quality of life thus effective for VD.

关 键 词：苯磺酸左旋氨氯地平 脑复康 血管性痴呆 

分 类 号：R972.4[医药卫生—药品] R969.4[医药卫生—药学]