1-芳酰基-4-取代吡唑甲酰基氨基硫脲和环化产物的合成及生物活性  

The Synthesis and Biological Activity of 1-Aryl-4-substituted Pyrazoloyl Thiosemicarbazides and Related Heterocyclic Compounds

作　　者：金桂玉[1] 侯震[1] 赵国锋[1] 曹春阳[1] 李煜昶[1] 

机构地区：[1]南开大学元素有机化学研究所,天津300071

出　　处：《高等学校化学学报》1997年第3期409-412,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：利用1-苯基-3-甲基-5-氯-4-吡唑甲酰基异硫氰酸酯（Ⅰ）与芳酰肼（Ⅱ）的加成反应合成了系列新的酰胺基硫脲衍生物（Ⅲ），并将Ⅲ在酸性条件下进行环化反应得到2-取代吡唑甲酰基氨基-5-芳基-1，3，4-噻二唑（Ⅳ）．生物活性测定结果表明部分化合物Ⅲ和Ⅳ具有较好的除草活性．A series of new acylthiosemicarbazide derivatives (Ⅲ ) were synthesized by addition reaction of 1-phenyl-3-methyl-5-chloro-4-pyrazoloyl isthiocyanate (Ⅰ) with aroyl hydrazines (Ⅱ), which were cyclized under an acidic condition to obtain 2-substituted pyrazoloyl amino-5-aryl-1, 3, 4-thiadiazoles (Ⅳ ). The preliminary biological tests indicate thatsome compounds of Ⅲ and Ⅳ show a good herbicidal activity.

关 键 词：酰胺基硫脲 除草活性 衍生物 环化 除莠剂 

分 类 号：O623.543[理学—有机化学] S482.4[理学—化学]