单核细胞增生李斯特菌PrfA蛋白转录调控毒力基因表达的分子机制  

Regulation of PrfA-dependent Virulence Genes Expression in Listeria monocytogenes

作　　者：罗勤[1] 张晓莉[1] 李兵[1] 冯爱平[2] 钱跃[2] 

机构地区：[1]华中师范大学生命科学,学院武汉430079 [2]华中科技大学附属协和医院皮肤科,武汉430022

出　　处：《微生物学通报》2008年第2期275-280,共6页Microbiology China

基　　金：国家自然科学基金项目(No.30500025);教育部211重点学科项目

摘　　要：单核细胞增生李斯特菌(Listeria monocytogenes LM)属于典型的细胞内寄生革兰氏阳性菌,是WHO公布的四大食源性致病菌之一。LM不仅是人畜共患传染病李斯特菌病(listeriosis)的主要病原菌,也是研究胞内感染和细胞介导的免疫应答的模式细菌。绝大多数LM毒力基因的转录表达受到PrfA蛋白的调控。本文简单介绍了LM侵染宿主细胞必需的毒力基因及其产物;重点对毒力基因调节蛋白PrfA的结构和功能,PrfA调节毒力基因表达的主要方式最新进展进行了综述和讨论。The gram-positive, facultative intracellular bacterium Listeria monocytogenes belongs to one of four severe food-borne pathogens issued by WHO. It is not only a causal agent of listeriosis caused infection of humans and animals, but also an important model system for the study of intracellular pathogens. Most of well-known listerial virulence genes are regulated by PrfA. The LM virulence genes involved in the infectious process and the PrfA-dependent virulence genes expression as well as putative regulative mechanisms were introduced and analyzed in this paper.

关 键 词：单核细胞增生李斯特菌 PrfA蛋白 毒力基因 表达调控 

分 类 号：Q93[生物学—微生物学]