头孢曲松引起急性间质性肾炎并肾功能衰竭  

Acute interstitial nephritis and renal failure due to ceftriaxone

作　　者：邹公民[1] 李丽萍 张学峰[1] 

机构地区：[1]荆州市第二人民医院药剂科,湖北荆州434000 [2]荆州市沙市区人民医院药剂科,湖北荆州434000

出　　处：《药物不良反应杂志》2008年第1期54-55,共2页Adverse Drug Reactions Journal

摘　　要：一名58岁男性,既往有胆结石、肾结石、前列腺肥大、2型糖尿病、高血压史,因胆囊炎接受头孢曲松(药量不详)治疗3d后,出现全身麻疹样红斑,继而出现眼睑和双下肢水肿。第12天尿常规显示:RBC(┼┼)～(┼┼┼),PRO(┼┼┼)。入院后肾功能检查显示:BUN43.20mmol/L、Cr1268.0μmol/L、UA855μmol/L,诊断为药物引起的急性间质性肾炎并急性肾衰竭。给予血液透析、抗感染、激素、利尿、补液等综合治疗。1个月后,患者皮疹和水肿完全消退,各项生化指标恢复正常。A 58-year-old man who had a history of cholelithiasis, renal lithiasis, prostatic hypertrophy, type 2 diabetes mellitus, and hypertension was prescribed with ceftriaxone （dosage not stated） for management of cholecystitis. After 3 days of treatment, he presented with generalized erythema morbilliforme and oedema of the eyelids and lower extremities. On day 12, an urine routine test showed the following values： RBC （＋＋） to（＋＋＋） ,PRO （＋＋＋）. After admission, the renal function tests revealed the following levels ： BUN 43.20 mmol/L, Cr 1 268.0 μmol/L, and UA 855 μmol/L. The patient was diagnosed with acute interstitial nephritis and acute renal failure. Combination therapy with haemodialysis, anti-infection, corticosteroid, diuretics, and fluid replacement was administered. One month later, erythema and oedema disappeared completely, and all biochemical values returned to normal ranges.

关 键 词：头孢曲松 急性间质性肾炎 肾功能衰竭 

分 类 号：R595.3[医药卫生—内科学]