胆南星不同炮制品的药效和毒性实验研究  

Pharmacological Study of the Rhizome Powder of Pinellia pedatisecta Processed by Different Procedures

作　　者：赫炎[1] 吴连英[1] 王孝涛[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中药材》1997年第9期459-461,共3页Journal of Chinese Medicinal Materials

摘　　要：以对戊巴比妥钠催眠作用影响为指标,比较研究不同胆南星炮制品的混悬液、水浸液、醇提物对昆明种小鼠的中枢系统抑制作用。同时对两种制品进行了急性毒副作用实验观察。结果:两种制品均未见毒副反应;两种制品的水浸液腹腔给药,均可增强戊巴比妥钠催眠作用;混合蒸制法醇提物腹腔给药较发酵法醇提物有明显的增强作用。The potentiation of hypnotic activity of a barbituate and acute tocicity by the rhizome powder of Pinellia pedatisecta Schott processed by pigbile with two different traditional medicinal procedures (fermentation mixing and heating alternatively) were studied in mice. The results showed that aquatic extracts of two processed drugs couldf potentiate the action of hypnotics; and ethanol extracts of the drug processed with mixing and heating alterntively could significantly enhance this action, compared with that of the drug pricessed with fermentation; while no acute toxicity was measured by the two processed drugs.

关 键 词：胆南星 天南星 炮制 药效 毒性 

分 类 号：R282.710.3[医药卫生—中药学]