不同强度脉冲电磁场对去势大鼠血清雌二醇的影响  

Effects of Different Intensity Pulsed Electromagnetic Fields on Serum Estradiol of Ovariectomized Rats

作　　者：杨永红[1] 何成奇[1] 杨霖[1] 王维[2] 雷中杰[1] 

机构地区：[1]四川大学华西医院康复科,成都610041 [2]苏州医学院附属医院康复科

出　　处：《四川大学学报（医学版）》2008年第2期256-258,共3页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(批准号30672215)资助

摘　　要：目的探讨不同强度的脉冲电磁场对于去势大鼠股骨骨密度及血清雌二醇的影响。方法采用随机数字表法将雌性3月龄SD大鼠分为:假手术组(SHAM)、去势大鼠模型对照组(OP模型)、以及不同频率脉冲电磁场治疗、、组(OVX、、)。去势造模后,OVX、和组大鼠每天在频率为8 Hz,磁通密度分别为0.77mT、3.82 mT和9.87 mT的磁场环境中照射40 min,共30 d。SHAM组和OP模型组不干预。30 d后股动脉放血处死大鼠,取左侧股骨作骨密度测定,取血清标本作血清雌二醇测定。结果与OP模型组相比,OVX、及组大鼠的股骨骨密度增加(P<0.05或P<0.01),但3组间及与SHAM组之间的差异无统计学意义;SHAM组大鼠的血清雌二醇水平均高于其它4组大鼠的血清雌二醇水平(P<0.05或P<0.01),但OP模型组、OVX、及组大鼠的血清雌二醇水平之间的差异无统计学意义。结论低频脉冲电磁场(PEMFs)能减少大鼠在卵巢切除后的骨量丢失、阻止骨密度下降。在磁场频率一致和干预时间相同的前提下,3种不同磁场强度(0.77 mT^9.87 mT)的PEMFs均有防止去势大鼠股骨骨密度降低的作用。同时,PEMFs并不能提高去势大鼠的血清雌二醇的水平,说明PEMFs对于骨质疏松的治疗作用不是由于提高了血清雌二醇的水平。Objective To explore the effects of different intensity pulsed electromagnetic fields （PEMFs） on serum estradiol in ovariectomized rats. Methods Fifty female SD rats were randomly divided into five groups： sham-operated control （no PEMF treatment）, ovariectomized control（no PEMF treatment）,ovariectomized group Ⅰ , Ⅱ, Ⅲ （PEMF treatment at 8 Hz frequency and 0. 77 mT,3.82 mT,9. 87 mT intensity, 40 min daily for 30 days）. Except for the sham-operated control rats, a standardized ovariectomy was used on every rat of other groups. The serum estradiol（E2） of rats was assessed at 30 days after PEMF treatment. Results The E2 values of the SHAM control group were significantly higher than those of other four groups （P〈0.05 or P〈0. 01）, but the difference in E2 values was not significant among the other four groups （P〉0.05）. Conclusion PEMFs can not improve the serum estradiol level of ovariectomized rat, it shows that the therapeutical effect of PEMFs is not due to improve the serum estradiol level.

关 键 词：磁场强度 低频脉冲电磁场 去势大鼠 骨密度 雌二醇 

分 类 号：R580[医药卫生—内分泌]