银屑病发病机制与Toll样受体  

Psoriasis pathogenesis and Toll-like receptors

作　　者：陈颖炜[1] 郑捷[1] 

机构地区：[1]交通大学医学院附属瑞金医院皮肤科,上海200025

出　　处：《国际皮肤性病学杂志》2008年第2期89-91,共3页International Journal of Dermatology and Venereology

摘　　要：有越来越多的证据显示银屑病是免疫介导的炎症过程，包括天然免疫和获得性免疫效应机制促进这种慢性皮肤病理过程。Toll样受体是对抗微生物侵入的天然免疫中的关键受体。这些受体不仅表达于外周血细胞也表达于气道上皮细胞和皮肤这些宿主和病原体相互作用部位的免疫细胞，也可能是触发或加重银屑病的微生物感染发生的部位。由于Toll样受体在触发天然免疫和影响获得性免疫中起重要作用，调节Toll样受体的表达可能与银屑病等疾病的病理生理相关。More and more evidences have shown that psoriasis is a chronic inflammation process mediated by immunity, including innate immunity and adaptive immunity. In the system of innate immunity, Toll-like receptors are the key receptors in protecting against microorganism intrusion. These receptors are expressed not only on peripheral blood cells, but also on epithelial cells in airway and immunocytes in epidermis, where pathogens may trigger the development or aggravate the activity of psoriasis. Therefore, regulating the expression of Toll-like receptors may affect the pathophysiology of many inflammatory diseases, such as psoriasis.

关 键 词：银屑病 免疫 TOLL样受体 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]