单药多西他赛治疗老年晚期非小细胞肺癌每周方案与每三周方案的疗效及毒性比较  

Comparison of curative effect and toxicity between every week method and every three-week method with docetaxel of injection therapy for senile advanced non-small cell lung cancer

作　　者：谢晓冬[1] 郑振东[1] 屈淑贤[1] 刘大为[1] 刘永叶[1] 张冠中[1] 朴瑛[1] 刘艳梅[1] 单学健[1] 

机构地区：[1]沈阳军区总医院肿瘤科,辽宁沈阳110016

出　　处：《中华肿瘤防治杂志》2008年第1期65-67,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了分析单药多西他赛治疗老年晚期非小细胞肺癌（non small cell lungcancer，NSCI．C）每3周方案与每周方案疗效与毒性的关系，对72例老年晚期NSCLC患者，其中40例（治疗组）接受每周方案，30～35mg／m^3，持续静脉滴入3h，d1、d8、d15休2周，为1个周期；32例（对照组）接受每3周方案，70mg／m^2，持续静脉滴入3h，每3周1次，为1个周期。结果治疗组CR、PR、SD、PD率、总有效率及1年生存率分别为2．5％（1／40）、37．5％（15／40）、32．5％（13／40）、27．5％（11／40）、40．0％（16／40）和47．5％（19／40），对照组分别为3．1％（1／32）、34．4％（11／32）、37．5％（12／32）、25．0％（8／32）、37．5％（12／32）和43．8％（14／32）。两者之间有效率和1年生存率差异无统计学意义，P=0．9920；P=0．6500；治疗组Ⅲ度以上骨髓抑制、消化道反应、口腔黏膜炎分别为3（7．5％）、6（15．0％）和7例（17．5％），而对照组分别为13（40．6％）、15（46．9％）和20例（62．5％）。两组之间差异有统计学意义，P〈0．05。初步研究结果显示，多西他赛单药每周方案治疗老年晚期NSCLC疗效与每3周方案大致相同，但不良反应轻微，更易被耐受。The objective of this study was to analyze curative effect and toxicity between every week method and every three-week method with docetaxel of injection therapy for senile advanced non-small cell lung cancer. Total 72 cases of senile advanced non small cell lung cancer took a cure,in which 40 cases were under treatment in every week method with a dose of 30 35 mg/m^2 ,d1 , d8, d13, at interval of 2 weeks for one cycle; 32 cases of the patients were under treatment in every three-week method with a dose of 70 mg/m^2 for one cycle of 3 weeks. In the therapeutic group, CR, PR, SD, PD, total effective rates and the 1-year survival rate were respectively 2.5% （1/40）, 37.5% （15/40）, 32.5%（13/40）, 27.5% （11/40）, 40.0%（16/40） and 47.5%（19/40）, while they were respectively 3. 1 （1/32）, 34.4%（11/32）, 37. 5%（12/32）, 25.0%（8/32）, 37.5%（12/32） and 43.8%（14/32）in the control group. And there was no statistic difference between them, P 0. 992 0, P=0. 650 0. There were 3 cases （7.5%）, 6 cases （15.0%） and 7 cases （17.5%） with arrest of bone marrow, alimentary tract reaction and mucous menbrane of mouth respectively over degree Ⅲ in the therapeutic group; and there were respectively 13 cases （40.6%）, 15 cases （46.9%） and 20 cases （62.5%） in the control group. There was significance of contrastive difference between the two groups. In conclusion, The curative effect between every week method and every three-week method with docetaxel of injection therapy for senile advanced non-small cell lung cancer is almost the same and the every week meth od is prone to tolerance with slight adverse reaction.

关 键 词：癌 非小细胞肺 抗肿瘤药 药物疗法 

分 类 号：R734.2[医药卫生—肿瘤]