^125I放射性粒子组织间植入治疗面神经受侵的腮腺恶性肿瘤初步临床观察  

Preliminary study of treating parotid gland malignant tumor with saving facial nerve （surgery associated with ^125I seed implant brachytherapy）

作　　者：张建国[1] 张杰[1] 宋铁砾[1] 郑磊[1] 蔡志刚[1] 俞光岩[1] 

机构地区：[1]北京大学口腔医学院·口腔医院口腔颌面外科,100081

出　　处：《中华口腔医学杂志》2008年第3期132-135,共4页Chinese Journal of Stomatology

基　　金：首都医学发展科研基金（2005-2006）

摘　　要：目的观察手术及在组织间植入放射性粒子^125I治疗腮腺恶性肿瘤并保存面神经的临床效果。方法32例腮腺恶性肿瘤患者手术切除肿瘤，解剖并保留受肿瘤侵犯的面神经。根据患者具体情况制定治疗计划、^125I组织间植入靶区设计，术中或术后植入放射性粒子^125I。定期随诊，观察肿瘤复发情况、面神经功能恢复及放射性损伤。结果32例患者随访12～44个月，未及肿瘤复发；未见明显放射性损伤症状。术后6个月患者面神经功能基本恢复正常。结论通过术中或术后植入^125I放射性粒子治疗面神经受侵的腮腺恶性肿瘤，可以保留受肿瘤侵犯的面神经功能，近期疗效满意。Objective To study the clinical effect of treating parotid gland malignant tumor with facial never-preserving surgery combined with ^125I seed implant brachytherapy. Methods Thirty-two patients with parotid gland malignancy underwent tumor and parotid gland excision while preserving facial never. According to treating plan system （ TPS）, ^1251 seeds were implanted into the target area during or after operation. The patients were followed up after operation and the local tumor control and facial nerve function were observed. Results Tumor recurrence was not found in any patient treated after 12 to 44 months of follow up. All patients did not show obvious radiation-related complications. The facial never function of all patients was basically normal 6 months after operation. Condusions For parotid gland malignant tumor, surgery combined with ^125I seeds implant brachytherapy can save facial never function, and the short-term effects were satisfactory.

关 键 词：面神经 腮腺肿瘤 近距离放射疗法 

分 类 号：R686[医药卫生—骨科学]