运动对胰岛素抵抗大鼠血清肿瘤坏死因子α水平的影响  

Effect of Exercise on Serum Level of Tumor Necrosis Factor-α in Insulin Resistant Rats

作　　者：肖方喜[1] 孙晖[1] 陈璐璐[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,武汉430022

出　　处：《中国康复》2008年第1期14-16,共3页Chinese Journal of Rehabilitation

基　　金：湖北省科技攻关基金资助项目(2005AA30C133)

摘　　要：目的:观察运动对高脂诱导胰岛素抵抗(IR)大鼠胰岛素敏感性的影响及血清肿瘤坏死因子α(TNF-α)水平的变化。方法:30只雄性大鼠分为对照组8只和高脂组22只,分别给予基础饲料与高脂饲料喂养18周,诱导IR大鼠模型,将IR成功大鼠分为高脂组A 10只,高脂组B 12只,均继续高脂饮食,高脂组B配合游泳训练6周。结果:高脂组大鼠与对照组比较,胰岛素敏感指数(ISI)显著降低,体重、血脂、血糖及血清TNF-α水平均升高,高脂组A更明显(均P<0.01);高脂组B训练后各项指标均与对照组接近。结论:运动可改善IR,其作用可能与降低血清TNF-α水平有关。Objective： To observe the effects of exercise on insulin sensitivity and serum level of tumor necrosis factor-a （TNF-α） in the insulin resistant rats induced by high fat diet. Methods： Swimming training was performed for 6 weeks in insulin resistant rats induced by high fat diet. The insulin sensitivity index was calculated. Changes of glucose and lipid metabolism were detected. Serum TNF-α level was detected by ELISA. Results： Compared to normal control group, the insulin sensitivity index in high fat diet group was decreased, while serum TNF-α level increased （both P〈 0.01）. Compared to high fat diet group, the insulin sensitivity index in swimming group was increased obviously, but the serum TNF-α level reduced by 31.1% after exercise for 6 weeks （both P〈0.05）. Conclusion： Exercise could improve insulin resistance through reducing the level of serum TNF-α.

关 键 词：运动 胰岛素抵抗 肿瘤坏死因子Α 

分 类 号：R87[医药卫生—运动医学] R587[医药卫生—临床医学]