高压氧对脑梗死患者血清一氧化氮及记忆商数的影响  

Influence of hyperbaric oxygen on serum nitric oxide and memory function in patients with cerebral infarction

作　　者：张树新[1] 彭争荣[2] 丁红[1] 

机构地区：[1]解放军总医院附属第二医院高压氧科,北京100091 [2]中南大学附属湘雅医院高压氧科

出　　处：《中华航海医学与高气压医学杂志》2008年第1期12-14,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨脑梗死患者高压氧治疗前后血清一氧化氮（NO）含量及记忆商数（MQ）得分的变化及两指标间的关系。方法将60例脑梗死患者分为高压氧组和药物对照组，测定2组患者治疗前后血清NO含量、MQ得分及两指标间的相关性。结果脑梗死后患者血清NO含量、MQ值均低于正常值，治疗后2组患者血清NO含量、MQ值均较治疗前显著提高，高压氧组NO含量、MQ值明显高于对照组（P〈0．05）。治疗后血清NO含量、MQ值间有显著的正相关性（P〈0．05）。结论高压氧能提高脑梗死患者的血清NO含量和MQ值，且NO与MQ之间有一定的正相关性，说明高压氧能进一步改善脑梗死患者脑组织的缺血、缺氧，修复神经元细胞及血管内皮细胞，增加NO的合成，从而进一步提高脑梗死患者的记忆水平。Objective To investigate the changes of serum nitric oxide （NO） and memory quotient （MQ） in patients with cerebral infarction before and after hyperbaric oxygen therapy （HBO） as well as the relationship between both of indexes. Methods Sixty patients with cerebral infarction were divided into two groups -HBO group and control group. The contents of serum NO and the scores of MQ in 60 patients before and after treatment were measured and the correlation between both of them were analyzed. Results The contents of NO and the scores of MQ in patients with cerebral infarction were lower than normal value. Whereas those of patients in the two groups were significantly higher after treatment than before, and those were significantly higher in HBO group than in control group（ P 〈0.05 ）. There was significantly positive correlation between the content of NO and the value of MQ after treatment （ P 〈 0.05 ）. Conclusions HBO can improve ischemic hypoxia of brain tissue, increase the synthesis of NO and further improve memory function in patients with cerebral infarction.

关 键 词：脑梗死 高压氧 一氧化氮 记忆商数 

分 类 号：R686[医药卫生—骨科学]