胺碘酮联合美托洛尔静脉注射治疗快速心律失常的临床观察  

Therapeutic outcome of intravenous amiodarone combined with metoprolol in the treatment of tachycardia

作　　者：左鹰[1] 于东明[1] 李建国[1] 

机构地区：[1]首都医科大学附属北京天坛医院急诊科,北京100050

出　　处：《第四军医大学学报》2008年第5期418-420,共3页Journal of the Fourth Military Medical University

摘　　要：目的:观察胺碘酮与美托洛尔联合治疗快速心律失常的即时疗效及安全性.方法:快速心律失常患者70例随机分成两组,分别静脉用胺碘酮(胺碘酮组)和胺碘酮与美托洛尔(胺碘酮+美托洛尔组).对两组患者用药后疗效、起效时间、血压、心率和不良反应进行比较.结果:胺碘酮+美托洛尔组窦性心律转复率及有效率高于胺碘酮组(94.4%vs70.6%,97.2%vs82.4%,P<0.05),起效时间(h)短于胺碘酮组[(0.5±0.2)vs(8.2±0.2),P<0.05〗;胺碘酮+美托洛尔组患者治疗后血压均显著下降(P<0.05),胺碘酮组治疗前后血压无统计学变化(P>0.05);两组患者治疗后心率(次/min)均下降(P<0.05),胺碘酮+美托洛尔组下降程度大于胺碘酮组[(98±21)vs(74±13),P<0.05〗;两组均未出现严重不良反应.结论:静脉联用胺碘酮与美托洛尔治疗快速心律失常安全且有效.AIM： To observe the acute efficacy and safety of intravenous amiodarone combined with metoprolol in the treatment of tachycardia. METHODS： Seventy patients with tachycardia were randomly divided into amiodarone group and amiodarone combined with metoprolol group. The therapeutic effect, effecting time, blood pressure, heart rate and adverse effect were compared between the 2 groups. RESULTS： The rates of sinus rhythm recovery and efficacy treated by amiodarone combined with metoprolol were signiiicantly higher than those treated by amiodarone （94.4% vs 70.6%, 97.2% vs 82.4%, P〈0.05）, and the effecting time of the amiodarone combined with metoprolol group was significantly shorter than that of the amiodarone group [ h, （0.5±0.2） vs （8.2±0.2）, P〈0.05]. The blood pressure level significantly decreased （ P 〈 0.05 ） in amiodarone combined with metoprolol group after treatment, while there was no signitcant change （ P 〉 0.05 ） in amiodarone group; the heart rates were significantly decreased in the 2 groups after treatment （ P 〈 0.05 ）, but the decrease was more obvious in the amiodarone combined with metoprolol group （ P 〈 0.05 ）. There was no obvious adverse effect in both groups. CONCLUSION： Intravenous amiodarone combined with metoprolol is effective and safe in the treatment of tachycardia.

关 键 词：胺碘酮 美托洛尔 心动过速 疗效 

分 类 号：R541.7[医药卫生—心血管疾病]