MPC骨水泥纤维蛋白胶复合BMP人工骨支架材料对山羊松质骨缺损的修复  

Experimental Study on Reparation Cancellous Bone Defects Using Magnesium Phosphate Cement and Fibrin Glue and Bone Morphogenic Protein Artificial Bone in Goat

作　　者：李毅[1] 孟国林[1] 刘建[1] 刘昌胜[2] 袁志[1] 吕荣[1] 

机构地区：[1]第四军医大学西京医院骨科,西安710032 [2]华东理工大学教育部医用生物材料工程研究中心,上海200237

出　　处：《科学技术与工程》2008年第6期1414-1418,共5页Science Technology and Engineering

基　　金：国家杰出青年基金(20425621)资助

摘　　要：研制MPC/CPC骨水泥纤维蛋白胶复合BMP新型人工骨的制备及人工骨修复骨缺损的性能。通过对成年山羊双侧股骨髁部分别制备1处直径10mm、深15mm松质骨缺损,制备MPC/CPC/FG/BMP(A组)、MPC/CPC/FG(B组)、CPC/FG(C组)人工骨支架材料,分别植入各组实验观察材料,分别于6周、12周进行影像学、组织学、形态计量学观察骨缺损修复情况。说明新型MPC骨水泥纤维蛋白胶复合BMP新型生物活性人工骨支架材料在促进成骨、加快磷酸钙骨水泥降解速度上优于MPC/CPC/FG、CPC/FG的人工骨,同时新型MPC骨水泥复合纤维蛋白胶的成骨和促骨水泥降解作用优于单纯CPC复合FG的人工骨。Artificial bone combined with BMP and MPC/CPC fibrin glue was processed and detected in the use of bone defect. The subjects were divided into 3 groups in random and were received scaffolds of MPC/CPC/FG/ BMP（ group A）, MPC/CPC/FG（ group B） and CPC/FG（ group C）respectively. The regeneration of bone was detected in X ray, histological staining and quantitative analysis. New scaffold combined with BMP and MPC/CPC fibrin glue was better than other scaffolds in osteogenesis and accelerating calcium phosphate cement decomposing.

关 键 词：骨缺损 人工骨 磷酸镁骨黏合剂 磷酸钙骨水泥 骨形态发生蛋白 

分 类 号：R318.08[医药卫生—生物医学工程]