L-精氨酸对高脂血症家兔主动脉和冠状动脉粥样硬化斑块面积的影响  

Effects of L-arginine on Atherosclerotic Plaque Area of Aortae and Coronary Arteries in Rabbit with Hypercholesterolemia

作　　者：焦鸿丽[1] 刘易林[2] 万腊香 胡隆梅 杨和平 杨永宗 

机构地区：[1]衡阳医学院分子生物学研究中心,衡阳421001 [2]广东省粤北地区人民医院,韶关市512026 [3]广州军区南岳制药厂,衡阳市421001

出　　处：《中国动脉硬化杂志》1997年第3期199-204,共6页Chinese Journal of Arteriosclerosis

摘　　要：选择健康雄性新西兰白兔144只（体重2．0～2．2kg），分为空白对照组、硝笨吡啶组、消心痛组、L-精氨酸组和高胆固醇组。预防性给药90天，治疗性给药是在预防性给药的基础上停喂胆固醇，其余处理因素不变，再观察90天。结果发现喂养1、1．5和2g／kgL-精氨酸均能减少高胆固醇血症所诱导的主动脉和冠状动脉粥样硬化斑块面积，硝笨吡啶组和消心痛组的病变重于L-精氨酸用药组，但比高胆固醇组轻。L-精氨酸（1g／kg）抗家兔动脉粥样硬化的效果优于硝苯吡啶（1．44mg／kg）及消心痛（2．88mg／kg）。以上结果表明，L-精氨酸有显著的抗实验性家兔动脉粥样硬化的作用，硝苯吡啶和消心痛也有类似作用，但效果不及L-精氨酸。Aim A large amount of literature reported that Larginine-nitric oxide (L-Arg--NO) pathway involVed in the formation and progression of atherosclerosis (As)induced by hypercholesterolemia. The purpose of this study is to determine the effects of L-arginine on the atherosclerotic plaque formation.Methods New Zealand white rabbits (n=144 ) were assigned to control group, nifedipine group,isosorbide dinitrate group, L-arginine group and hypercholesterolemic group, respectively. Experiment included a 90 days' treatment and 180 days' treatment.The percentage of atherosclerotic plaque covering aortic and coronary intima was measured.Results The atherosclerotic plaque area was reduced by feeding with L-arginine at l, 1. 5 and 2 g/kg in each day at this study. While in nifedipine treated groups and in isosorbide dinitrate treated groups, the plaque area gave higher values than L-arginine treated groups, but lower than those of hypercholesterolemic groups. The effects of L-arginine on antiatherosclerosis was more significant than nifedipine and isosorbide dinitrate.Conclusion L-arginine exerts strong antiatherosclerotic effect in experimental rabbit. Nifedipine and isosorbide dinitrate has the similar effect but with a slightly weaker action.

关 键 词：高脂血症 L-精氨酸 动脉粥样硬化 

分 类 号：R543.505[医药卫生—心血管疾病] R589.205[医药卫生—内科学]