老年人颈动脉壁内膜和中膜厚度与高胆固醇血症和其它危险因素的关系  

The Association of Carotid Arterial Intima-media Thickness with Hypercholesterolemia and Other Risk Factors in the Elderly

作　　者：叶平[1] 王节[1] 杨丙建[1] 尚延忠[1] 

机构地区：[1]中国人民解放军总医院老年心内科,北京100853

出　　处：《中国动脉硬化杂志》1997年第3期234-237,共4页Chinese Journal of Arteriosclerosis

摘　　要：采用高分辨率B型超声显象法检测94例不同血清胆固醇水平的老年人的颈动脉内膜和中膜厚度，旨在探讨老年人的颈动脉内膜和中膜厚度与冠心病及高胆固醇血症等心血管病危险因素的关系。结果发现，不同胆因醇水平的三组间内膜和中膜厚度差异无显著性，但颈动脉内膜和中膜厚度与年龄、收缩压、总胆固醇和低密度脂蛋白胆固醇水平有显著的正相关性。内膜和中膜厚度增加者（≥1．0mm）吸烟、高血压病、冠心病及脑梗塞的发生率明显高于内股和中膜厚度正常者（＜1．0mm）。Logistic多因素回归分析发现年龄是内膜和中膜厚度增加的独立影响因素。因此，多种因素不同程度地影响老年人的颈动脉内膜和中膜厚度．颈动脉内膜和中膜厚度作为一种无创性检查指标可用于观察老年人动脉粥样硬化的变化情况。Aim The aim of this study was to evaluate the association of carotid arterial intima-media thickness(IMT) with coronary heart disease (CHD) and risk factors of cardiovascular disease.Methods IMT was measured by high resolusion Bmode ultrssound in 94 elderly subjects. The studied population were divided into three groups:① 32 subjects with normal cholesterol; ② 16 subjects with bordline hypercholesterolemia; ③ 46 subjects with hypercholesterolemia.Results The IMT was not significantly different among three groups with various cholesterol levels,whereas the IMT was positively correlated with age,blood pressure, serum total cholesterol and LDL cholesterol. The incidences of hypertension, smoking, cerebral infarction and CHD were obviously highten in the subjects with IMT>1. 0 mm compared with IMT<1.0 mm. Age was determined as an independent factor for intima-media thickening on multivariate Logistic regression. Conclusion Carotid artery IMT was affected, to various extent, by multi-factors in the elderly. Carotid arterial IMT, as a noninvasive index, could be used to observe the change of atherosclerosis in the elderly.

关 键 词：高胆固醇血症 颈动脉 中膜厚度 内膜厚度 

分 类 号：R589.202[医药卫生—内分泌]