糖尿病视网膜病变患者红细胞膜Ca^(2+)-Mg^(2+)-ATPase活性变化及相关研究  

A study of Ca^(2+)-Mg^(2+)-ATpase Activity in Erythrocyte Membrane from Diabetic Retinopathy Patients

作　　者：何剑峰[1] 仇宜解[1] 鲍连云[1] 张立贵[1] 朱膺均 

机构地区：[1]青岛医学院附属医眼科

出　　处：《临床眼科杂志》1997年第3期138-140,共3页Journal of Clinical Ophthalmology

摘　　要：目的探讨糖尿病视网膜病变发生发展的有关因素。对40例糖尿病机网膜病变患者红细胞膜Ca^(2+)－Mg^(2+)－ATPasc活性进行了检测，并与红细胞内Ca^(2+)－Ms^(2+)－ATPasc含量、空腹血糖、糖基化血红蛋白及红细胞变形指数等进行了分析。结果糖尿病机网膜病变患者红细胞膜Ca^(2+)－Ms^(2+)－ATPasc活性显著下降（P＜0．01），细胞内Ca^(2+)含量增加（P＜0．01）而Mg^(2+)含量则显著下降（P＜0．01）。糖尿病视网膜病变者红细胞膜Ca^(2+)－Ms^(2+)－ATPasc活性下降与空腹血糖、糖基化血红蛋白、红细胞变形指数及红细胞内Ca^(2+)－Ms^(2+)－ATPasc含量等变化密切相关。结论糖尿病视网膜病变患者红细胞膜Ca^(2+)－Ms^(2+)－ATPasc活性异常下降可能是导致或加速视网膜病变发生发展的原因之一。To study the correlative factor about the occurrence and development of diabetic retinopathy(DR). Methods Ca^(2+)-Mg^(2+)-ATPase activity in ery-throcyte membrane was investigated in 40 Patients with DR. The relation of Ca^(2+)-Mg^(2+)-ATPase activity with content Ca2+ and Mg2+ in erythrocyte, fasting biood -glucoae (FBG ), hemoglobin glycosylation (HBAlc ), and erythrocythe filterability index (EFI)was also studied.Results Ca^(2+)-Mg^(2+)-ATPase activity in reythrocyte membrane was singnificantly decreased in DR (P <0. 01 ). The defect was acconipaned by, an increase in erythrocyte Ca2t (P < 0.01 )2nd a decrease in erytho-cyte Mg'+ (P <0. 01). The decrease of Ca^(2+)-Mg^(2+)-ATPase activity in erythrocyte in DR was connected with the cllanges of FBG, HbAlc, EFI, and the content of Ca2+ and Mg2+ in erythrocyte. Conclusiou The de-crease of Ca^(2+)-Mg^(2+)-ATPase activity in erythrocyte membrane may contribute to the occurrence and devel-opment of DR.

关 键 词：糖尿病 视网膜病变 红细胞膜 钙 镁 ATP酶 

分 类 号：R587.202[医药卫生—内分泌] R774.120.2[医药卫生—内科学]