炎症反应在慢性阻塞性肺疾病伴发肺动脉高压中的作用  

Inflammatory reaction in chronic obstructive pulmonary disease with pulmonary arterial hypertension

作　　者：倪惠娟[1] 解卫平[1] 

机构地区：[1]南京医科大学第一附属医院呼吸科,210029

出　　处：《国际呼吸杂志》2008年第5期315-317,共3页International Journal of Respiration

摘　　要：炎症反应在慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）伴发肺动脉高压的发生、发展中起着重要作用。气道存在炎症时，激活的炎症细胞释放肿瘤坏死因子α（TNF-α）、白介素6（IL-6）和IL-8等多种细胞因子，共同参与气道壁、肺泡壁的结构破坏和重塑。这些气道炎症反应不仅影响已存在缺氧的COPD伴肺动脉高压患者，也可影响尚不存在缺氧的COPD伴肺动脉高压患者，可能是早期COPD患者肺动脉重塑及血流动力学改变的始动环节。Inflammatory reaction plays an important role in chronic obstructive pulmonary disease （COPD） with pulmonary arterial hypertension （PAH）. When airway inflammation exists, the active inflammatory cells release many cytokines such as tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6）, interleukin-8（IL-8） and so On. They participate in destroying and remodeling of airway wall and alveolar wall together. The effect of airway inflammatory reaction occurs not only in patients already being hypoxic, but also in patients not being hypoxic. It may be the beginning link of pulmonary arterial remodeling and changes of hemodynamics for COPD patients in early stage.

关 键 词：炎症反应 慢性阻塞性肺疾病 肺动脉高压 

分 类 号：R563.9[医药卫生—呼吸系统]