含哌啶取代酞菁金属配合物的合成及其对癌细胞光灭活作用  

Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell

作　　者：黄紫洋[1] 薛金萍[1] 陈锦灿[2] 陈耐生[1] 黄金陵[1] 

机构地区：[1]福州大学功能材料研究所 [2]中国科学院福建物质结构研究所,福州350002

出　　处：《高等学校化学学报》2008年第3期445-448,共4页Chemical Journal of Chinese Universities

基　　金：福建省科技厅重点科研项目(批准号:2006Y0020);福建省自然科学基金(批准号:E0513011)资助

摘　　要：采用'模板法'合成8种含哌啶取代酞菁金属配合物[(PEO)4PcM,M=Zn,Ni,Co,Cu,PEO=2-(哌啶-1-基)乙氧基],采用FTIR、质谱和元素分析等技术对其进行了表征.分别测定了它们的紫外-可见吸收光谱、荧光发射光谱和光敏化产生单线态氧的能力.研究结果表明,2种酞菁锌配合物均具有较高的摩尔消光系数、一定的荧光量子产率和较大的单线态氧生成速率.通过光动力灭活BEL7402肝癌细胞的试验研究发现,β-(PEO)4PcZn的浓度为10μmol/L时,在670nm激光辐照下,光剂量为1.2J时,对癌细胞的抑制率可达到83%.＂The template approach＂ was used for the synthesis of eight metal phthalocyanine complexes containing piperidine group （PEO） 4 PcM, where M = Zn, Ni, Co, Cu, PEO = 2- （piperidin-1-yl） ethyoxyl. These complexes were characterized by FTIR, mass spectrum, elemental analysis and so on. The UV-Vis absorption spectra, fluorescence emission spectra and capacity of photo-generating singlet oxygen were examined. The resuits showed that two zinc phthalocyanine complexes possessed high molar extinction coefficient, fluorescence quantum yield, high rate of photo-generating singlet oxygen. The complex with formulaβ- （PEO） 4 PcZn had a photoinhibition effect to BEL7402 liver cancer cells up to 83 % in case that the irradiation with 670 nm laser light （ dosage 1.2 J） and the concentration ofβ- （PEO） 4 PcZn with 10μmol/L were used.

关 键 词：酞菁金属配合物 N-哌啶乙醇 合成 光灭活作用 

分 类 号：O611.4[理学—无机化学] R979.1[理学—化学]