靶控输注丙泊酚与舒芬太尼联合用于无痛人工流产术的临床研究  

The Anesthetic Effect of Target-Controlled Infused Propofol Combined with Sufentanil in Painless Artificial Abortion

作　　者：贾真[1] 刘晓明[2] 朱平增[1] 陈声荣[3] 徐静芳[3] 徐建国[3] 

机构地区：[1]武警河南总队医院麻醉科,河南郑州450052 [2]上海交通大学医学院附属新华医院麻醉科,上海200092 [3]南京军区南京总医院,江苏南京210002

出　　处：《实用妇产科杂志》2008年第2期97-100,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨不同血浆靶浓度丙泊酚靶控输注(TCI)联合一定剂量舒芬太尼用于无痛人工流产手术的合理配伍。方法:80例早孕患者,随机分为4组。Ⅰ组单纯用1%丙泊酚,血浆靶浓度设定为7.0μg/ml,Ⅱ、Ⅲ、Ⅳ组在输注丙泊酚前2分钟先静脉注射0.12μg/kg舒芬太尼,注药时间30秒,Ⅱ、Ⅲ、Ⅳ组丙泊酚血浆靶浓度分别设定为5.0μg/ml、5.5μg/ml、6.0μg/ml。待患者睫毛反射消失,双频脑电图值(BIS)降至40后开始手术,吸宫结束时停丙泊酚。监测患者的收缩压(SBP)、舒张压(DBP)、脉膊氧饱和度(SPO2)、HR和BIS值,并记录诱导时间、手术时间、唤醒时间和定向力恢复时间、丙泊酚的总用量、患者体动及术后宫缩痛等情况。结果:与对照组相比,各舒芬太尼组的丙泊酚用量均降低,其唤醒时间、定向力恢复时间较短,血流动力学亦较平稳,术后宫缩痛明显减轻。结论:采用5.5μg/ml丙泊酚TCI与0.12μg/kg舒芬太尼配伍用药,丙泊酚用量小,患者呼吸抑制轻,体动反应弱,血流动力学稳定,术后苏醒迅速,为最适丙泊酚TCI浓度。Objective：To explore the reasonable target plasma concentration of propofol combined with sufentanil in anesthesia of painless artificial abortion. Methods： Eighty patients were randomly divided into four groups, group I only accepted propofol at plasma concentration of 7.0μg/ml. Group II, III, and IV accepted injection of Sufentenil （0.12μg/kg） combined with propofol of plasma concentration at 5.0μg/ml, 5.5μg/ml, and 6.0μg/ml respectively. Patients＇ SBP, blood pressure, SpO2, HR, and BIS were monitored. Induction time, oparaticn time, awake time, orientaticn recovery time, overall consumption of propofol, patients＇ body motion, and postoperative uterine contraction pain were observed.Results：Compared with group Ⅰ , groups Ⅱ, Ⅲ, and IV had less overall consumption of propofol, shorter awake time and orientation recovery time, with more stable hemodynamics and less postoperative uterine contraction pain. Conclusions. Target plasma propofol concentration of 5.5μg/ml combined with sufentanil （0.12μ/kg） gives more efficient anesthesia and better recovery with fewer complications in painless artificial abortion.

关 键 词：靶控输注 无痛人工流产 丙泊酚 舒芬太尼 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]