白芨超微粉对大鼠实验性胃溃疡的影响  

Effect of ultra-fine powder of Bletilla striata on experimental gastric ulcer in rats

作　　者：刘莹[1] 崔炯莫[1] 李洪斌[2] 王艳萍[2] 汤真[2] 于海瑶[2] 吴艳云[2] 

机构地区：[1]延边大学,吉林延吉133000 [2]中国人民解放军第208医院,吉林长春130062

出　　处：《中草药》2008年第3期397-400,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(30672672)

摘　　要：目的通过大鼠胃溃疡实验比较白芨普通粉(80、200目)和超微粉的药效学区别及白芨经超微粉碎后可降低的用药剂量。方法采用大鼠无水乙醇和醋酸致胃黏膜损伤型胃溃疡模型,测定溃疡面积,计算溃疡抑制率;取溃疡部组织切片,做HE染色,从病理学角度进一步观察病理情况。结果白芨粉可明显降低大鼠的溃疡面积,且超微粉疗效优于普通粉。结论超微粉碎后有助于提高白芨的药效,减少用药剂量,有利于剂型现代化。Objective To compare the pharmacodynamics of common Bletilla striata powder （80 and 200 meshes） with ultra-fine powder of B. striata on experimental gastric ulcer in rats and to clarify how much the dose of B. striata was decreased after superfine comminution. Methods The models of gastric ulcer were set up by anhydrous alcohol and acetic acid to measure the gastric ulcer area and count out the inhibitory rate ; The tissue slice of gastric ulcer cicatrix was got far HE staining. Based on the viewpoint of pathology the morbid state was observed. Results B. striata powder could decrease the gastric ulcer area significantly, and the groups of ultra-fine powder were advantaged to the others. Conclusion After su- perfine comminution, the potency of B. striata can he improved with its dose reducing. It is good for modernization of making dosage forms.

关 键 词：超微粉 白芨 胃溃疡模型 

分 类 号：R286.1[医药卫生—中药学]