丹参总酚酸对博莱霉素致肺纤维化小鼠的治疗作用  

Therapeutic effect of total salvianolic acid on mice with pulmonary fibrosis induced by Bleomycin

作　　者：林军[2,3,5] 冯一中[2] 顾振纶[1,3] 武慧[2,3] 周文轩[3,4] 郭次仪[3,4] 

机构地区：[1]苏州大学医学院药理教研室,江苏苏州215123 [2]苏州大学医学院病理教研室,江苏苏州215123 [3]苏州中药研究所,江苏苏州215007 [4]香港保健协会,中国香港 [5]上海市第一人民医院病理科

出　　处：《中草药》2008年第3期400-403,共4页Chinese Traditional and Herbal Drugs

基　　金：香港保健协会基金资助项目(20050916-2HK)

摘　　要：目的观察丹参总酚酸对博莱霉素致肺纤维化小鼠的治疗作用。方法通过气管内注射博莱霉素复制小鼠肺纤维化模型,给予丹参总酚酸ig治疗后,以肺指数、肺组织病理形态及羟脯氨酸(Hyp)水平的测定,观察丹参总酚酸对小鼠肺纤维化形成的影响。结果丹参总酚酸治疗后肺泡炎和肺纤维化明显减轻,Hyp水平比模型组明显降低(P<0.05、0.01)。结论丹参总酚酸能减轻博莱霉素致小鼠肺纤维化程度,有一定的治疗作用。Objective To study the therapeutic effects of total salvianolic acid on Bleomycin-induced pulmonary fibrosis in mice. Methods The pulmonary fibrosis model was established by intratracheal in- iection of Bleomycin. The lung index, pathomorphology, and level of hydroxyproline （Hyp） in lung tissue were measured to observe the effect of total salvianolic acid on pulmonary fibrosis of mice. Results Total salvianolic acid could obviously reduced alveolitis and fibrosis. The lung index was significantly decreased in total salvianolic acid group compared with that in model group, and the level of Hyp was significantly lower than that in model group （P〈0.05 and 0.01）. Conclusion Total salvianolic acid could have therapeutic effects on Bleomycin-induced pulmonary fibrosis in mice.

关 键 词：肺纤维化 丹参总酚酸 羟脯氨酸 

分 类 号：R286.1[医药卫生—中药学]