多巴酚丁胺对血管内皮细胞单层通透性的影响  

Effects of Dobutamine on Permeability to the Serum Lipids of Vascular Endothelial Cell Monolayers

作　　者：董海兴 王晓峰[1,2] 

机构地区：[1]大连市解放军医高专 [2]大连市解放军第210医院

出　　处：《解放军医学高等专科学校学报》1997年第1期26-28,共3页Clinical Journal of Medical Officer

摘　　要：实验研究了β激动剂多巴酚丁胺在人脐静脉内皮细胞单层上对血浆脂类通透性的影响。结果显示该药能够降低血管内皮细胞单层对水、胆固醇、甘油三酯、载脂蛋白Ａ和载脂蛋白Ｂ的通透性。提示：多巴酚丁胺可减少脂类和载脂蛋白对血管内皮下渗入，因而可能具有抗动脉粥样硬化的作用。The effects of beta adremocetor agonists dobutamine on the permeability to the serum lipids in Vascular endothelial cell monolayers were investigated.It is found that the drug can decrease the permeability of confluent vascular endothelial cell monolayers to water, cholesterol, triglyceride, lipoprotern A and B significantly.These results suggest that dobutamine may decrease the infiltration of lipids and lipoproteins to the subendothelial space, thus it can be used to prevent and inhibit atheosclerosis.

关 键 词：血管内皮细胞 通透性 多巴酚丁胺 药物 

分 类 号：R972.6[医药卫生—药品]