左旋卡尼汀对缺血心肌能量代谢和心功能的影响  

The Effects of L-Carnitine to the Energy Metabolism of Ischemical Reperfusion Myocardium

作　　者：张丽[1] 高春霖[1] 

机构地区：[1]天津医科大学第二医院麻醉科,天津300211

出　　处：《医学综述》2008年第5期755-757,共3页Medical Recapitulate

摘　　要：左旋卡尼汀,又称肉碱,由哺乳动物体内自身合成。左旋卡尼汀的作用是协助长链脂酰辅酶A进入线粒体内膜,进行脂肪酸β-氧化提供能量,加速三磷酸腺苷(ATP)的产生,提高心肌细胞内ATP水平。许多研究表明,左旋卡尼汀可以改善缺血心肌的功能和促进能量代谢。L-camitine, also called novain, is synthezised by mammal themselves. It helps long-chain acyl-CoA enter into mitochondrial inner membrane, supply energy for fatty acid carrying out β-oxiation and increasing the levels of the adenosine triphosphate in myocardial cell. Many researches showed that L-camiline can improve functions and energy metabolism of the ischemia myocardium.

关 键 词：左旋卡尼汀 缺血心肌 缺血再灌注损伤 能量代谢 

分 类 号：R977[医药卫生—药品]