上海“6.25”钴源辐射事故受照者淋巴细胞微核17年随访观察  

A Follow-up Survey of the Lymphocyte Micronucleus for Three Victims Seventheen Years After Shanghai "6.25" ^(60)Co Radiation Accident.

作　　者：杜杰[1] 陈英[1] 闫学昆 张学清[1] 刘秀林[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所 [2]解放军96615部队

出　　处：《中国辐射卫生》2008年第1期5-6,共2页Chinese Journal of Radiological Health

摘　　要：目的对上海"6.25"钴源事故3名受照者照后17年进行随访,为评价辐射对人体的远后效应及其临床意义提供依据。方法照后17年抽取静脉血,以松胞素-B微核分析法观察微核(MN)率及其微核细胞(MNC)率。结果照后17年,MN、MNC率仍高于正常参考值;MNC中的MN出现频率仍与早先受照剂量相关,含2个以上的MN的MNC数以受照剂量最大的"龙"最高,"俊"次之,而受照剂量最低的"军"则以含一个MN的MNC为主;照后第17年的MN和MNC率低于照后第5年,但高于照后第10年。结论微核分析是辐射远后效应的重要观察指标之一,17年后,微核在体内仍然以较高的水平长期存在值得注意。Objective To study the long - term effect on lymphocyte micronucleus and its clinical significance for the three victims seventheen years after Shanghai ＂6.25＂60Co radiation accident. Method The MN and MNC frequency were observed by CBMN method . Results The MN and MNC frequency were still higher than normal even 17 years after the exposure. The MN frequency is related with the former radiation dose. The MNC consisting of ≥2MN is the hightest for ＂Long＂, but for＂Jun＂it consisted of 1 MN. The MN frequency is lower 17 years after the exposure than that of 5 years ,but higher than 10 years. Conclusions The MN is one of important signs for long - term radiation effect. Special attention should be payed to the high level of MN remaining in the body for so long time.

关 键 词：辐射事故 微核 微核细胞 远后效应 

分 类 号：R816.3[医药卫生—放射医学]