伍用雌孕激素对雷公藤致雌鼠生殖系统损害的保护作用  

Protective effect of hormone replacement therapy on the changes of female rat genital system induced by tripterygiumw ilfordiipo lyglycosidium

作　　者：黄婷[1] 徐星铭[1] 郝丽[1] 王瑞峰[1] 卢文[1] 袁亮[1] 

机构地区：[1]安徽医科大学第一附属医院肾脏内科,合肥230022

出　　处：《安徽医科大学学报》2008年第1期32-35,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:070413066)

摘　　要：目的观察雷公藤多苷伍用雌孕激素对雌鼠生殖系统的影响。方法将具有正常动情周期的雌性大鼠随机分为3组,以生理盐水组为对照,观察雷公藤多苷(TWP)组及TWP伍用激素替代治疗(TWP+HRT)组大鼠子宫卵巢的重量、动情周期、血清雌激素(E2)、卵泡刺激素(FSH)、黄体生成素(LH)水平及卵巢子宫的病理变化。结果与对照组相比,TWP组大多动情周期延长或紊乱,E2降低(P<0.05),FSH及LH水平升高(P<0.05),卵巢及子宫重量明显下降(P<0.05),卵巢各级卵泡减少,子宫内膜变薄,腺体减少;TWP+HRT组无明显改变。结论在TWP治疗的同时伍用HRT可减少TWP对雌鼠生殖系统的损伤,保护卵巢功能。Objective To observe the effect of Estrogen-progestogen sequential therapy on the changes of female rat genital system induced by tripterygiumw ilfordiipo lyglycosidium. Methods Thirty female rats with normal oestrus cycle were randomly divided into 3 groups, Normal sodium was gived in control group. The weight of the ovary and uterus , oestrus cycle , the level of E2 , FSH and LH and pathological change of the ovary and uterus were observed in TWP group and TWP combined with hormone replacement therapy group （ TWP ＋ HRT）. Results Compared with control group, oestrus cycle was abnormal, estrogen level and the weight of the ovary and uterus lowered （ P 〈 0. 05 ）, the level of FSH and LH increased （P 〈 0. 05 ）, follicle grew badly, endometrium was thin with diminishing uterine gland in TWP group; No obvious change was found in TWP ＋ HRT group. Conclusion TWP combined with HRT can decrease the toxic and side effects of TWP on the genital system of female rat and protect the ovary.

关 键 词：雌激素类/治疗应用 孕激素类/治疗应用 雷公藤/副作用 生殖器/药物作用 

分 类 号：R977.12[医药卫生—药品] R282.71[医药卫生—药学]