当归分散片处方与直接压片工艺的研究  

A Study on the Prescription and Technique of Direct Powder Compression of Angelicae Sinensis Dispersible Tablet

作　　者：白洁[1] 何应[1] 

机构地区：[1]天津大学药物科学与技术学院,300072

出　　处：《医药导报》2008年第3期315-318,共4页Herald of Medicine

摘　　要：目的制备服用方便、起效迅速的当归分散片。方法通过实验筛选填充剂、崩解剂等辅料,采用粉末直接压片工艺制备当归分散片,以崩解时限、混悬性等因素为指标,通过正交实验对处方进行筛选。结果优选处方为Prosolv含量34%,交联羧甲基纤维素钠10%,可压性淀粉5%,微粉硅胶1%,对优选处方的实验表明:崩解时间<3 min;分散均匀性和混悬性较好;15 min溶出度>80%。结论该方法简单,可靠,优选处方的当归分散片达到《中华人民共和国药典》(2005年)的要求。Objective To prepare angelicae sinensis dispersible tablet with characteristics of conveniently application and quickly action. Methods Both diluents and disintegrants were screened. Direct powder compression technique was used to prepare angelicae sinensis dispersible tablet. The prescription was assessed by particularities of disintegration time and suspension stability. Results An optimal prescription assembly was 50% of angelicae sinensis extract,34% of prosolv,10% of cCMC-Na, 5% of amylum pregelatinisatum, 1% of colloidal silicon dioxide. The test showed that disintegration time was less than three minutes, both dispersible homogeneity and suspension stability were good, and dissolution rate at 15 minutes was more than 80%. Conclusions The technique was simple and reliable. The angelicae sinensis dispersible tablets with optimal prescription could meet the dispersible tablets requirements of Chinese Pharmacopoeia published in 2005.

关 键 词：当归 分散片 正交实验 混悬性 

分 类 号：R944.4[医药卫生—药剂学] TQ460.6[医药卫生—药学]