利用SPSS估算一级吸收米氏消除药物的药动学参数  

Estimation of the Pharmacokinetic Parameters for Drugs Obeying One Order Adsorption and Michaelis-Menten Elimination by SPSS

作　　者：苏银法[1] 

机构地区：[1]浙江省温州市第二人民医院药剂科,325000

出　　处：《医药导报》2008年第3期333-336,共4页Herald of Medicine

基　　金：温州市科技局社会发展基金资助项目(基金编号:Y2003A075)

摘　　要：目的估算米氏消除药物血管外给药的药动学参数。方法四阶Runge-Kutta算法获得血药浓度的模拟值,根据模拟取样点的药时数据,以△C/△t近似地代替微分式dC/dt,血药浓度(C)采用算术均数(Ci+Ci+1)/2;采用SPSS软件中的非线性回归(non linear regression)对△C/△t-C数据对拟合药动学参数。结果SPSS估算的药动学参数准确可靠。结论SPSS可用于估算米氏消除药物血管外给药的药动学参数。Objective To estimate the pharmacokinetic parameters for drug obeying one order adsorption and Michaelis-Menten elimination by SPSS（statistics package for social science, 12.0） software. Methods Concentration-time data obtained from four order Runge-Kutta algorism with excel forms were converted into △C/△t at a sere of sampling time. The dC/dt was approximately replaced by △C/△t,and concentration c was accounted by an arithmetic mean of（Ci＋Ci＋1）. Data of A C△/△ t-c were analogized by nonlinear regression of SPSS. Results The pharmacokinetic parameters estimated by SPSS were accurate and reliable. Conclusion SPSS is suitable for estimating the pharmacokinetic parameters of drugs obeying one order adsorption and Michaelis-Menten elimination.

关 键 词：SPSS软件 药动学 米氏消除 一级吸收 

分 类 号：R969.1[医药卫生—药理学]