脂联素基因Gly15Gly多态性与糖尿病大血管病变的关系  

Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus

作　　者：艾智华[1] 房殿春[1] 张忠辉[2] 

机构地区：[1]第三军医大学西南医院全军消化病研究所,重庆400038 [2]第三军医大学西南医院内分泌科,重庆400038

出　　处：《第三军医大学学报》2008年第6期536-538,共3页Journal of Third Military Medical University

基　　金：国家“十五”攻关项目(2001BA702B01,2001BA702B04)~~

摘　　要：目的探讨脂联素基因Gly15Gly多态性与糖尿病早期大血管病变发生的关系。方法运用多聚酶链式反应-限制性片段长度基因多态性(PCR-RFLP法)分析方法,对56例伴大血管病变和120例无大血管病变的2型糖尿病患者脂联素基因Gly15Gly多态性位点进行基因分型。结果大血管病变组GG基因型频率(25.0%)显著高于无血管病变组(6.2%),G等位基因频率显著升高(P<0.05);GG基因型血浆脂联素水平显著低于TT和TG基因型。结论脂联素基因Gly15Gly多态性与糖尿病大血管并发症的发生有关,脂联素基因+45位点GG基因型是2型糖尿病大血管并发症的易感基因型。Objective To investigate the association adiponectin gene polymorphism with primary macroangiopathy in diabetes mellitus. Methods Type 2 diabetes mellitus （T2DM） patients were included, 56 patients complicated with atherosclerosis （AS） and 120 non-AS group. We evaluated their Glyl5Gly polymorphism of adiponectin gene by PCR restriction fragment length polymorphis＇m （PCR-RFLP）. Results The AS patients were more likely to have GG genotype than the non-AS patients （25.0% vs 6.2%, P 〈0.05）. Blood adiponectin in the patients with GG genotype was lower than that in ones with TY or TG genotype [ （ 15.10 ± 7.04） g/ml vs （19.64±6.64） g/ml and （18.38 17.49） g/ml]. Conclusion Gly15Gly polymorphism of adiponectin gene is related to primary macrovascular complications in T2DM. GG genotype is probably the predisposing gene for primary macrovascular complications in T2DM.

关 键 词：脂联素 基因多态性 糖尿病 大血管病变 

分 类 号：R341[医药卫生—基础医学] R394.3