腹膜透析患者钙磷代谢紊乱的相关研究  

Disorders of calcium and phosphorus metabolism in patients undergoing peritoneal dialysis

作　　者：高峰[1] 王宝仁[1] 贺晓[1] 王欢[1] 吴琼[1] 

机构地区：[1]武警辽宁总队大连医院肾内科,大连116013

出　　处：《武警医学》2008年第3期217-220,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨腹膜透析(CAPD)患者钙磷代谢平衡的调节及肾性骨病的防治。方法所有患者化验血钙、血磷、肌酐、甲状旁腺素等生化指标,而后根据不同的残余肾功能、钙磷乘积值、透析液日交换剂量、透析时间长短分组。结果腹膜透析患者普遍存在钙磷代谢紊乱,钙磷乘积升高组血磷、甲状旁腺素值高,透析时间长(P<0.05);随透析剂量增加血磷、血肌酐值下降(P<0.05);残余肾多的患者血磷、钙磷乘积值降低(P<0.05)。结论腹膜透析患者普遍存在钙磷代谢紊乱,以钙磷乘积及血磷升高为突出表现。残余肾功能对于血磷的清除起重要作用。Objective To investigate the regulation of calcium - phosphorus metabolism balance and treatment of renal osteodystrophy in patients undergoing pecitoneal diclysis. Methods Serum calcium, phosphorus, creatinine, and parathyrin were analyzed in the peritoneal dialysis patients. The patients were divided into groups according to their residual renal ftmction, calcium - phosphorus product, dose of peritoneal dialysate exchanged everyday, and the duration of dialysis. Results The disorders of calcium and phosphorus metabolism existed commonly. The patients with higher calcium - phosphorus product had higher serum phosphorus and PTH contents and longer dialysis time（ P 〈 0.05） .Along with the increase of dialysis dose ,the serum phosphorus and creatinine contents decrensed （ P 〈 0.05） .The higher residual renal function,the lower serum phosphorus content and calcium - phosphorus product（ P 〈0. 05）. Conclusions Disorders of calcium and phosphorus metabolism are common and widespread in patients undergoing peritoneal dialysis. The high serum phosphorus level and calcium - phosphorus product are remarkable manifestations. The residual renal ftmction plays an important role in the clearance of serum phosphorus.

关 键 词：腹膜透析 钙磷代谢 钙磷乘积 残余肾功能 

分 类 号：R459.5[医药卫生—治疗学]