复方薤白胶囊治疗慢性支气管炎急性发作期的Ⅱ期临床研究  

Clinical Trial of Compound Xiebai Capsule for the Treatment of Acute Exacerbation of Chronic Bronchitis

作　　者：杨仁旭[1] 胡勇刚[1] 景瑞 杜建霖[1] 何祝萍[1] 任颖[1] 刘松山[1] 

机构地区：[1]成都中医药大学附属医院,成都610075 [2]南京厚生药业有限公司,南京210007

出　　处：《中药新药与临床药理》2008年第2期149-152,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的观察复方薤白胶囊治疗慢性支气管炎急性发作期痰热郁肺证的安全性和有效性。方法采用随机、双盲单模拟、阳性药平行对照方法。试验组口服复方薤白胶囊,每次4粒,每日3次;对照组口服芩暴红止咳胶囊,每次2粒,每日3次。疗程均为10d。结果试验组临床控制32例,显效45例,有效34例,无效9例;对照组临床控制21例,显效54例,有效36例,无效9例。两组显效率和总有效率相近(P>0.05);服药第5天对咳嗽症状的改善,试验组优于对照组(P<0.05)。治疗组有3例出现白细胞减少,未经特殊处理自行恢复。结论复方薤白胶囊治疗慢性支气管炎急性发作期痰热郁肺证是安全、有效的。Objective To make an objective evaluation of Compound Xiebai Capsule （CXC） in the treatment of the acute exacerbation of chronic bronchitis （AECB） with phlegm and heat stagnating the lung. Methods A randomized, double - blind, single - simulation, parallel positivedrug control trial was performed. The test group received oral use of CXC, 4 capsules per time, 3 times a day the control group received Qinbaohong Zhike Capsule, 2 capsules, 3 times a day. Treatment lasted 10 days. Results In test group, 32 cases were clinically controlled, 45 markedly effective, 34 effective and 9 cases ineffective; in the control group, 21 cases were clinically controlled, 54 markedly effective, 36 effective and 9 invalid. The effective rate and total effective rate were similar in the two groups （ P 〉 0. 05） ; the relief of cough in the test group was superior to that in the control group in the fifth day after medication （ P 〈 0.05）. There are 3 cases of leukopenia in test group, but it can restore normal without treatment. Conclusion Compound Xiebai capsule in the treatment of AECB with phlegm and heat stagnating the lung is safe and effective.

关 键 词：复方薤白胶囊 慢性支气管炎 痰热郁肺证 

分 类 号：R285.6[医药卫生—中药学]