脉搏波波形特征信息检测及与部分血流动力学变化相关分析  

Detection of waveform characteristic of pulse wave and analysis of its related partial hemodynamic changes

作　　者：张俊利[1] 蔺嫦燕[1] 杨琳[2] 张松[2] 吴广辉[1] 李小帅[2] 

机构地区：[1]首都医科大学北京安贞医院生物医学工程研究室,北京100029 [2]北京工业大学生命科学与生物工程学院,北京100022

出　　处：《生物医学工程与临床》2008年第2期104-107,共4页Biomedical Engineering and Clinical Medicine

基　　金：北京市科技计划项目(Z0005190042011)

摘　　要：目的引入特征点——收缩期与舒张期分界点,提出脉搏波波形周期面积特征,讨论脉搏波波形周期面积特征量与血流动力学参数的相关关系。方法选择笔者所在医院门诊病人424例,采集桡动脉脉搏波信号,分析其波形周期面积特征(收缩期面积特征量K1和舒张期面积特征量K2)与血流动力学参数[心输出量(CO)、血流阻力(TPR)和血液黏度(V)]的相关性。结果脉压差与K1高度正相关(P<0.01),与K2高度负相关(P<0.01),与K1/K2高度正相关(P<0.01)。年龄与K1高度正相关(P<0.01),与K2高度负相关(P<0.01),与K1/K2高度正相关(P<0.01)。K1与CO高度负相关(P<0.01),K2与CO负相关(P<0.05),K1/K2与CO无明显相关。K1、K2分别与TPR高度正相关(P<0.01),K1/K2与TPR无明显相关。K1、K2分别与V高度正相关(P<0.01),K1/K2与V高度负相关(P<0.01)。结论试验表明,脉搏波波形周期面积特征量代表人体心血管系统中最为重要的一些生理参数如血管外周阻力、血液黏性等的变化。Objective To propose the characteristics of waveform cycle area by introducing the demarcation of systolic phase and diastolic phase, and propose cycle area of waveform characteristic, and discuss the correlation of cycle area of waveform characteristics and hemodynamic parameters. Methods A total of 424 outpatients were collected their pulse wave signals of radial artery, and compared the cycle area of waveform characteristic with hemodynamic parameters. Results The cycle area of waveform characteristic positively correlates with pulse pressure difference, age and some hemodynamic parameters. Conclusion It is demonstrated that the cycle area of waveform characteristic could represent the changes of some important human physiological parameters such as peripheral vascular resistance, blood viscosity and so on.

关 键 词：波形周期面积特征 收缩期面积特征量 舒张期面积特征量 特征比例 

分 类 号：R318.01[医药卫生—生物医学工程]