人类群体遗传空间结构异质性变异函数模型  

Spatial semivariogram models of human population genetic structure

作　　者：邵琦[1] 薛付忠[1] 王洁贞[1] 成玉[1] 张桂琴[1] 

机构地区：[1]山东大学公共卫生学院流行病与卫生统计学研究所,济南250012

出　　处：《山东大学学报（医学版）》2008年第2期111-114,127,共5页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金资助项目(30170527)

摘　　要：目的建立人类群体遗传空间结构异质性变异函数模型。方法结合地理距离和遗传距离的关系,分别建立基于三种经典遗传距离的群体遗传空间结构异质性的变异函数模型。结果实例表明,模型客观地反映了人类群体遗传空间结构异质性和空间自相关性。结论人类群体遗传空间结构异质性变异函数模型可以揭示人类群体遗传空间结构特征。Objective To establish a spatial semivariogram model of human population genetic structure. Methods Spatial semivariogram models were set up based on genetic distance by analyzing the relationship between geographic distance and genetic distance. Results The spatial semivariogram model revealed the spatial genetic structures of a human population, Conclusion Spatial semivaringram models of human population genetic structure can effectively reveal the spatial structure of the population genetic structure.

关 键 词：人类群体遗传空间结构 空间异质性 变异函数模型 

分 类 号：R195.1[医药卫生—卫生统计学]