老年人阻塞性睡眠呼吸暂停综合征与脑白质疏松的关系  

Relationship between leukoaraiosis and obstructive sleep apnea/hypopnea syndrome in elderly patients

作　　者：饶丽芬[1] 莫建伟[1] 郑勤伟[1] 欧琼[1] 

机构地区：[1]广东省人民医院老年医学研究所,广州510080

出　　处：《中华神经医学杂志》2008年第3期308-310,共3页Chinese Journal of Neuromedicine

基　　金：广东省卫生厅基金（A2005010）

摘　　要：目的探讨老年人阻塞性睡眠呼吸暂停综合征（OSAHS）与脑白质疏松（LA）之间的关系。方法对应用多导睡眠呼吸监测诊断的169例OSAHS患者进行头颅磁共振检查．评估LA的发生率及其程度，探讨睡眠呼吸参数与LA程度的关系。结果169例0SAHS患者中无LA24例（14．20％）；LA145例（85．80％），其中轻度LA27例（15．98％），中度LA65例（38．46％），重度LA53例（31．36％）。对不同程度LA患者年龄、体重指数及睡眠呼吸参数进行比较发现，年龄、睡眠呼吸紊乱指数（AHI）、平均血氧饱和度（MSaO2）、SaO2〈90％时间及氧减指数各组间差异有统计学意义（p〈0．05）。经Logistic回归分析，年龄及氧减指数与LA密切相关。结论随着年龄的增加，氧减指数逐渐增大，LA发生率逐渐增加，程度逐步加重。对OSAHS患者采取适当的干预措施有利于改善LA引起的认知功能障碍等症状。Objective To study the relationship between the leukoaraiosis （LA） and obstructive sleep apnea/hypopnea syndrome （OSAHS） in the elderly. Methods 169 cases of OSAHS diagnosed by polysomnogram （PSG） underwent brain MRI to evaluate the incidence and degree of LA and to explore the relationship between LA and OSAHS in the elderly. Results LA was found in 145 （85.80%） of 169 OSAHS cases, and among them, mild LA in 27 cases （15.98%）, moderate in 65 （38.46%） and severe in 53 （31.36%）. There was a significant correlation of LA with age, oxygen desaturation index, MSaO2 sleep time spent when SaO2 〈 90%, apnea hyponea index （AHI） （P〈0.05）. By multivariate regression analyses, age and oxygen desaturation index were the most vital effective factors for LA. Conclusions With the increase of patients＇age and oxygen desaturation index, LA becomes more common and aggravated. Appropriate interventive treatment for OSAHS will be able to ameliorate the LA-induced cognitive dysfunction.

关 键 词：脑白质疏松 睡眠呼吸暂停 阻塞性 老年人 

分 类 号：R766[医药卫生—耳鼻咽喉科] R742.89[医药卫生—临床医学]