急性冠脉综合征病人的纤溶系统与血管内皮功能关系  

The Relationship between Fibrinolytic System and Vascular Endothelial Function in Acute Coronary Syndrome

作　　者：李朝鹏[1] 刘志远[2] 张连彦[2] 

机构地区：[1]邢台医学高等专科学校 [2]河北省复员军人医院

出　　处：《中西医结合心脑血管病杂志》2008年第3期258-260,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究血管内皮功能与急性冠脉综合征病人纤溶指标的关系。方法以健康体检者(42例)为对照组,稳定型心绞痛(SAP)组43例,急性冠脉综合征(ACS)组52例,分别采用高分辨超声技术检测血流介导和硝酸甘油介导的肱动脉舒张功能,并测定血浆组织型纤溶酶原激活物(t-PA)、血浆纤溶酶原激活物抑制剂(PAI-1)。结果ACS组的PAI-1(69.40±5.73)ng/mL明显高于对照组及SAP组(P<0.05),t-PA明显低于对照组及SAP组(P<0.05)。ACS病人的血管内皮功能(FMD)为(7.57±6.30)%,明显低于对照组(12.26±4.33)%及SAP组(11.25±3.08)%(P<0.05)。ACS病人的FMD与PAI-1水平显著负相关,相关系数r=-0.8115(P<0.05)。结论PAI-1可能是反映急性冠脉综合征病人血管内皮功能的血液标志物。PAI-1含量增高也可为临床诊断ACS提供依据。Objective To study the relationship between the endothelium function and fibrinolysis system in patients （pts） with acute coronary syndrome （ACS）. Methods There were three groups were design to study： Control group （ n = 42）, stable angina pectoris group （SAP group, n = 43） and ACS group （n = 52）. The brachial artery flow mediated dilatation （FMD） and nitroglycerin--induced dilatation （NID） was measured by high resolution ultrasound technique. Tbe serum concentration of plasminogen activator inhibitor （PAl- 1 ） and tissue- type plasminogen activator （t - PA） were measured. Results PAI-1 （69.40 ± 5.73） ng/mL in ACS group was significantly higher than that in control group and SAP group （ P〈 0.01 ）, t - PA （ 10.57 ± 5.15） in ACS group was significantly lower than that in control group and SAP group （P〈0.01）. There were no significant differences between thc control group and SAP group. Vascular endothelial function （ 7.57 ± 6.30 ） % in ACS group was significantly lower than that in control group （ 12.26 ± 4.33 ） % and SAP group （ 11.25 ± 3.08 ） % （ P 〈 0.01 ）. There were no significant differences between the control group and SAP group. There was significant negative correlation between FMD function and PAl 1 in ACS （r= -0.8115, P〈0.05）. The equation was Y= 69. 54 - 0. 89X （P〈0.05）. Conclusion PAl - 1 might be a blood marker of vascular endothelial function in pts with ACS. The increased PAI-1 could provide evidences for clinical diagnosis of ACS.

关 键 词：急性冠脉综合征 纤溶酶原激活物 血管内皮功能 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]