转化生长因子及其受体在烧伤治疗中的作用  

Function of TGFs and Its Receptor

作　　者：史绯绯[1] 夏晓燕[2] 

机构地区：[1]河南科技大学第一附属医院烧伤整形科,洛阳市471003 [2]河南科技大学医学院,洛阳市471000

出　　处：《医药论坛杂志》2008年第5期37-39,共3页Journal of Medical Forum

摘　　要：目的通过免疫组织化学和原位杂交对正常皮肤和增生性瘢痕中转化生长因子S(TGFs)及其受体TGFRI、TGFRII表达的研究,探讨TGFs及其受体在正常皮肤和增生性瘢痕中的表达以及在增生性瘢痕形成中的作用,为临床治疗提供理论依据。方法选取瘢痕疙瘩标本10例、正常皮肤标本7例,采用免疫组化方法检测TGFs及其受体。结果石蜡切片HE染色示正常皮肤和增生性瘢痕皮肤结构不同,增生性瘢痕皮肤组织炎性细胞浸润和新生血管增生明显多于正常皮肤;免疫组化结果显示增生性瘢痕皮肤组织TGF1、TGF2和TGFRI较正常皮肤呈现较强的表达,而TGF3和TGFRII的表达与正常皮肤相比,表达信号相对较弱。结论TGFs及其受体在正常皮肤和增生性瘢痕中的表达不同。Objective To investigate the express of TGF s and its receptor TGF RI,TGF RII in the normal skin and hyperplastic scar by immunohistochemistry and in situ hybridization to find the expression of TGF s and its receptor in the normal skin and hyperplastic scar and their function in the process of hyperplastic scar＇s formation. Methods Select 10 samples of keloid, 7 samples of normal skin, detect their TGF s and its receptor by immunohistochemistry. Results The skin structure is different between normal skin and hyperplastic scar through HE dyeing and paraffin section, the skin tissue of hyperplastic scar has more inflammatory cell infiltrate and new blood vessel hyperplasia than normal skin; the result of immunohistochemistry indicate that the skin tissue of hyperplastic Scar has a higher expression of TGF 1, TGF 2 and TGF RI than normal skin. However the expression of TGF 3 and TGF RII is lower than normal skin. Conclusion The expression of TGF s and its receptor is different between hyperplastic scar and normal skin.

关 键 词：TGFs 受体 增生性瘢痕 

分 类 号：R644[医药卫生—外科学]